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Titolo:
O-1-[3-(N-METHYLPYRROLIDIN-2R-YLMETHYL)INDOL-5-YL] BENZIMIDAZOLE (CP-161,242) - A POTENT, CENTRALLY ACTIVE 5-HT1D RECEPTOR AGONIST AND BENZODIAZEPINE PARTIAL AGONIST
Autore:
MACOR JE; BLANK DH; DESAI K; FOX CB; KOE BK; LEBEL LA; POST RJ; SCHMIDT AW; SCHULZ DW; SEYMOUR PA;
Indirizzi:
ASTRA ARCUS USA,POB 20890 ROCHESTER NY 14602 PFIZER INC,DIV CENT RES,DEPT MED CHEM GROTON CT 06340 PFIZER INC,DIV CENT RES,DEPT NEUROSCI GROTON CT 06340
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 20, volume: 5, anno: 1995,
pagine: 2391 - 2396
SICI:
0960-894X(1995)5:20<2391:OB(>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRICTED PHENOLIC ANALOG; NEUROTRANSMITTER SEROTONIN; 5-METHOXY-3-(1,2,5,6-TETRAHYDROPYRID-4-YL)INDOLE; LIGANDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Macor et al., "O-1-[3-(N-METHYLPYRROLIDIN-2R-YLMETHYL)INDOL-5-YL] BENZIMIDAZOLE (CP-161,242) - A POTENT, CENTRALLY ACTIVE 5-HT1D RECEPTOR AGONIST AND BENZODIAZEPINE PARTIAL AGONIST", Bioorganic & medicinal chemistry letters, 5(20), 1995, pp. 2391-2396

Abstract

The discovery of CP-161,242 pyrrolidin-2R-ylmethyl)indol-5-yl]benz-imidazole), a potent, selective, orally active central serotonin (5-HT1D) agonist [IC50 (binding) = 1.3 nM, EC(50) (inhibition of adenylate cyclase) = 42 pM] and benzodiazepine ligand [IC50 (binding) = 3.3 nM], is presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:52:18