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Titolo:
THE EFFECT OF FLUORINE SUBSTITUTION ON THE HAEMOTOXICITY OF PRIMAQUINE
Autore:
ONEILL PM; TINGLE MD; MAHMUD R; STORR RC; WARD SA; PARK BK;
Indirizzi:
UNIV LIVERPOOL,DEPT CHEM,POB 147 LIVERPOOL L69 3BX MERSEYSIDE ENGLAND UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT LIVERPOOL L69 3BX MERSEYSIDE ENGLAND
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 20, volume: 5, anno: 1995,
pagine: 2309 - 2314
SICI:
0960-894X(1995)5:20<2309:TEOFSO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIMALARIAL DRUG PRIMAQUINE; METABOLITES; GLUTATHIONE; OXIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Oneill et al., "THE EFFECT OF FLUORINE SUBSTITUTION ON THE HAEMOTOXICITY OF PRIMAQUINE", Bioorganic & medicinal chemistry letters, 5(20), 1995, pp. 2309-2314

Abstract

5-Fluoro-6-methoxy-8-nitroquinoline was synthesised by a modified Skraup Reaction and was subsequently converted into 5-fluoroprimaquine inthree steps. 5-Fluoroprimaquine 9 is less susceptible to in vitro bioactivation than primaquine 1 in a range of different species. However,significant bioactivation of 9 was observed with hepatic microsomes from two species including man.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:37:45