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Titolo:
CALORIMETRIC STUDY ON THE SYNTHETIC PENTAPEPTIDE THYMOPENTIN INTERACTION WITH PHOSPHOLIPID-MEMBRANES - EFFECT OF STEARYLAMINE AND PH
Autore:
CASTELLI F; PANICO A; PIGNATELLO R; MAZZONE P;
Indirizzi:
UNIV CATANIA,DIPARTIMENTO SCI CHIM,VIALE A DORIA 6 I-95125 CATANIA ITALY UNIV CATANIA,IST CHIM FARMACEUT & TOSSICOL,CATTEDRA TECN & LEGISLAZ FARMACEUT I-95125 CATANIA ITALY UNIV CATANIA,IST SCI BIOCHIM & FARMACOL I-95125 CATANIA ITALY
Titolo Testata:
Journal of colloid and interface science
fascicolo: 2, volume: 175, anno: 1995,
pagine: 289 - 292
SICI:
0021-9797(1995)175:2<289:CSOTSP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE-TRANSITIONS; LIPOSOMES; SYSTEMS;
Keywords:
LIPOSOMES; THYMOPENTIN; STEARYLAMINE; CALORIMETRY; DIPALMITOYLPHOSPHATIDYLCHOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
F. Castelli et al., "CALORIMETRIC STUDY ON THE SYNTHETIC PENTAPEPTIDE THYMOPENTIN INTERACTION WITH PHOSPHOLIPID-MEMBRANES - EFFECT OF STEARYLAMINE AND PH", Journal of colloid and interface science, 175(2), 1995, pp. 289-292

Abstract

We propose a calorimetric study of phospholipid model membranes (DPPC) interacting with stearylamine (SA) and a short polypeptide. A pentapeptide, thymopentin (TP5), whose sequence is Arg-Lys-Asp-Val-Tyr, was studied and the following aspects were examined: (a) effect of increasing amount of SA on DPPC liposomes, (b) effect of TP5 on pure DPPC liposomes at different pH, and, (c) effect of TP5 on model mixture of DPPC-SA at different pH. Results show that pH plays a fundamental role inmodulating TP5 interaction with zwitterionic DPPC membranes. This interaction becomes more complex in the presence of high SA concentrationin the membrane, because of the opposite charges gained by SA and TP5at acidic or alkaline pH. The pH-induced charges cause either a larger stabilization or fluidification of the DPPC-SA bilayer. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:58:42