Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
POTENT INHIBITION OF REPLICATION OF PRIMARY HIV TYPE-1 ISOLATES IN PERIPHERAL-BLOOD LYMPHOCYTES BY NEGATIVELY CHARGED HUMAN SERUM ALBUMINS
Autore:
GROENINK M; SWART PJ; BROERSEN S; KUIPERS M; MEIJER DKF; SCHUITEMAKER H;
Indirizzi:
UNIV GRONINGEN,DEPT PHARMACEUT PHARMACOL & CLIN PHARM,ANTONIUS DEUSINGLAAN 1 NL-9713 AV GRONINGEN NETHERLANDS NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT CLIN VIROIMMUNOL NL-1066 CX AMSTERDAM NETHERLANDS UNIV AMSTERDAM,EXPT & CLIN IMMUNOL LAB NL-1066 CX AMSTERDAM NETHERLANDS UNIV GRONINGEN,CTR PHARM,DEPT PHARMACEUT PHARMACOL & CLIN PHARM NL-9713 AW GRONINGEN NETHERLANDS
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 2, volume: 13, anno: 1997,
pagine: 179 - 185
SICI:
0889-2229(1997)13:2<179:PIOROP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; RECOMBINANT SOLUBLE CD4; AIDS-RELATED COMPLEX; DEXTRAN SULFATE; BIOLOGICAL PHENOTYPE; CELL-CULTURE; T4 ANTIGEN; INFECTION; RECEPTOR; TROPISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
M. Groenink et al., "POTENT INHIBITION OF REPLICATION OF PRIMARY HIV TYPE-1 ISOLATES IN PERIPHERAL-BLOOD LYMPHOCYTES BY NEGATIVELY CHARGED HUMAN SERUM ALBUMINS", AIDS research and human retroviruses, 13(2), 1997, pp. 179-185

Abstract

We previously reported the antiviral capacity of human serum albumin (HSA), which was modified by the introduction of a single (Suc-HSA) ortwo carboxylic groups (Aco-HSA) per lysine residue, yielding stronglynegatively charged polypeptides, Here we report the antiviral effect of these modified HSAs on replication of primary HIV-1 isolates that differed with respect to syncytium-inducing (SI) capacity and cell tropism. Both Suc-HSA and Aco-HSA potently inhibited replication of primary HIV-1 variants, independent of the SI capacity of the HIV-I variant,with IC50 values in the range of 50 to 187 mu g/ml. The inhibition ofthe formation of syncytia and the absence of proviral DNA products incells inoculated with HIV-1 in the presence of Suc-HSA or Aco-HSA pointed to interference at an early level in the virus replication cycle. The inhibitory capacity of Suc-HSA and Aco-HSA on primary HIV-1 variants suggests that these agents are potential candidates for use in antiviral therapy in HIV-infected individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:48:55