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Titolo:
DIETARY ANTIOXIDANTS AND CAROTID-ARTERY WALL THICKNESS - THE ARIC STUDY
Autore:
KRITCHEVSKY SB; SHIMAKAWA T; TELL GS; DENNIS B; CARPENTER M; ECKFELDT JH; PEACHERRYAN H; HEISS G;
Indirizzi:
UNIV TENNESSEE,DEPT PREVENT MED,DIV BIOSTAT & EPIDEMIOL,877 MADISON AVE MEMPHIS TN 38163 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV N CAROLINA,SCH PUBL HLTH,CTR COLLABORAT STUDIES COORDINATING,DEPT BIOSTAT CHAPEL HILL NC 00000 UNIV N CAROLINA,SCH PUBL HLTH,DEPT EPIDEMIOL CHAPEL HILL NC 00000 DEPT LAB MED & PATHOL MINNEAPOLIS MN 00000 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103
Titolo Testata:
Circulation
fascicolo: 8, volume: 92, anno: 1995,
pagine: 2142 - 2150
SICI:
0009-7322(1995)92:8<2142:DAACWT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; FOOD FREQUENCY QUESTIONNAIRE; NUTRITION INTERVENTION TRIALS; DISEASE-SPECIFIC MORTALITY; CORONARY HEART-DISEASE; VITAMIN-E CONSUMPTION; D-ALPHA-TOCOPHEROL; B-MODE ULTRASOUND; OXIDATIVE MODIFICATION; CARDIOVASCULAR-DISEASE;
Keywords:
ANTIOXIDANTS; DIET; CAROTID ARTERIES; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Kritchevsky et al., "DIETARY ANTIOXIDANTS AND CAROTID-ARTERY WALL THICKNESS - THE ARIC STUDY", Circulation, 92(8), 1995, pp. 2142-2150

Abstract

Background Evidence that dietary antioxidants may prevent atherosclerotic disease is growing. The relationship between the intake of dietary and supplemental vitamin C, alpha-tocopherol, and provitamin A carotenoids and average carotid artery wall thickness was studied in 6318 female and 4989 male participants 45 to 64 years old in the Atherosclerosis Risk in Communities Study. Methods and Results Intake was assessed by use of a 66-item semiquantitative food-frequency questionnaire. Carotid artery intima-media wall thickness was measured as an indicatorof atherosclerosis at multiple sites with B-mode ultrasound. Among men and women >55 years old who had not recently begun a special diet, there was a significant inverse relationship between vitamin C intake and average artery wall thickness adjusted for age, body mass index, fasting serum glucose, systolic and diastolic blood pressures, HDL and LDL cholesterol, total caloric intake, cigarette use, race, and education (test for linear trend across quintiles of intake, P=.019 for womenand P=.035 for men). An inverse relationship was also seen between wall thickness and alpha-tocopherol intake but was significant only in women (test for linear trend, P=.033 for women and P=.13 for men). There was a significant inverse association between carotene intake and wall thickness in older men (test for linear trend, P=.015), but the association weakened after adjustment for potential confounders. No significant relationships were seen in participants <55 years old. Conclusions These data provide limited support for the hypothesis that dietaryvitamin C and alpha-tocopherol may protect against atherosclerotic disease, especially in individuals >55 years old.

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Documento generato il 04/12/20 alle ore 16:26:36