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Titolo:
A STUDY OF BIOCHEMICAL MARKERS OF REPERFUSION EARLY AFTER THROMBOLYSIS FOR ACUTE MYOCARDIAL-INFARCTION
Autore:
LAPERCHE T; STEG PG; DEHOUX M; BENESSIANO J; GROLLIER G; ALIOT E; MOSSARD JM; AUBRY P; COISNE D; HANSSEN M; ILIOU MC;
Indirizzi:
HOP BEAUJON,DEPT CARDIOL,SERV CARDIOL,100 BD GEN LECLERC F-92118 CLICHY FRANCE HOP BICHAT,DEPT CARDIOL F-75877 PARIS FRANCE HOP COTE DE NACRE,DEPT CARDIOL CAEN FRANCE HOP CENT,DEPT CARDIOL NANCY FRANCE HOP HAUTE PIERRE,DEPT CARDIOL STRASBOURG FRANCE HOP MILETRIE,DEPT CARDIOL POITIERS FRANCE CLIN ST JOSEPH,DEPT CARDIOL COLMAR FRANCE HOP BROUSSAIS,DEPT CARDIOL F-75674 PARIS FRANCE HOP BICHAT,DEPT BIOCHEM F-75877 PARIS FRANCE
Titolo Testata:
Circulation
fascicolo: 8, volume: 92, anno: 1995,
pagine: 2079 - 2086
SICI:
0009-7322(1995)92:8<2079:ASOBMO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY REPERFUSION; CREATINE-KINASE ISOFORMS; INTRAVENOUS THROMBOLYSIS; THERAPY; PERFUSION; MYOGLOBIN; PLASMA; RECANALIZATION; ANGIOPLASTY; MB;
Keywords:
MYOCARDIAL INFARCTION; REPERFUSION; MYOGLOBIN; CREATINE KINASE; TROPONIN T;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Laperche et al., "A STUDY OF BIOCHEMICAL MARKERS OF REPERFUSION EARLY AFTER THROMBOLYSIS FOR ACUTE MYOCARDIAL-INFARCTION", Circulation, 92(8), 1995, pp. 2079-2086

Abstract

Background In acute myocardial infarction (AMI), early noninvasive identification of patients with occluded infarct-related arteries (IRAs)after thrombolysis has important prognostic and therapeutic implications. The aims of this study were to evaluate biochemical methods for the early diagnosis of patency after thrombolysis prospectively and to establish the optimal diagnostic criteria retrospectively. Methods andResults In 97 patients with AMI treated with thrombolytic agents lessthan or equal to 6 hours after the onset of symptoms, myoglobin, troponin T, creatine kinase, the MB isoenzyme and MM isoforms of creatine kinase were measured just before thrombolysis began and 90 minutes later. IRA patency was assessed by means of 90-minute coronary angiography. For each marker, compared with the expected sensitivity and specificity based on published thresholds for the diagnosis of patency, the observed values were consistently lower but were markedly improved in asubset of patients treated >3 hours after the onset of symptoms. Withreceiver-operator characteristic curve analysis of the slopes of increase and relative increases in each marker over 90 minutes, the best diagnostic performance was achieved by use of the relative increase in myoglobin, troponin T, and MM3/MM1 creatine kinase isoforms in patients treated >3 hours after onset (areas under the curve of 0.84, 0.83, and 0.85, respectively).Conclusions Effective early noninvasive diagnosis of patency after thrombolysis is possible in patients treated >3 hours after symptom onset by use of criteria derived from the relative increase over 90 minutes in plasma markers, particularly myoglobin, troponin T, and MM3/MM1 creatine kinase isoforms. The diagnostic performance of the relative increase in myoglobin appears to be less susceptible to small changes in the diagnostic threshold value.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:29:21