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Titolo:
HIV-1 MESSENGER-RNA IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS AS AN EARLYMARKER OF RISK FOR PROGRESSION TO AIDS
Autore:
SAKSELA K; STEVENS CE; RUBINSTEIN P; TAYLOR PE; BALTIMORE D;
Indirizzi:
ROCKEFELLER UNIV,BOX 285,1230 YORK AVE NEW YORK NY 10021 NEW YORK BLOOD CTR NEW YORK NY 10021 MIT CAMBRIDGE MA 02139
Titolo Testata:
Annals of internal medicine
fascicolo: 9, volume: 123, anno: 1995,
pagine: 641 -
SICI:
0003-4819(1995)123:9<641:HMIPMA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CD4 LYMPHOCYTE COUNTS; ANTIGEN CAPTURE ASSAY; NEW-YORK-CITY; HOMOSEXUAL MEN; TYPE-1 INFECTION; VIRAL BURDEN; SERUM BETA-2-MICROGLOBULIN; DISEASE PROGRESSION; PROGNOSTIC VALUE;
Keywords:
HUMAN IMMUNODEFICIENCY VIRUS; ACQUIRED IMMUNODEFICIENCY SYNDROME; RNA, MESSENGER; LEUKOCYTES, MONONUCLEAR; BIOLOGICAL MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
K. Saksela et al., "HIV-1 MESSENGER-RNA IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS AS AN EARLYMARKER OF RISK FOR PROGRESSION TO AIDS", Annals of internal medicine, 123(9), 1995, pp. 641

Abstract

Objective: To establish human immunodeficiency virus type 1 (HIV-1) messenger RNA (mRNA) expression in peripheral blood mononuclear cells as a marker of risk for progression to the acquired immunodeficiency syndrome (AIDS) in a large cohort of HIV-infected persons followed for aprolonged period. Design: Retrospective testing of cryopreserved, coded specimens. Setting: Research laboratories at the New York Blood Center and the Rockefeller University. Patients: 150 homosexual men infected with HIV-I who did not have an AIDS diagnosis at the time of testing. Measurements: Multiply spliced and unspliced HIV-I mRNAs in total peripheral blood mononuclear cell RNA were quantitated using reverse transcriptase-initiated polymerase chain reaction (PCR) and compared with other laboratory data and clinical outcome during the subsequent 8 years. Results: Although HIV-1 mRNA expression generally correlated with immunologic status, it was associated with future disease progression independently of CD4(+) cell counts or their rate of decrease at the time of sampling. The association of HIV-1 mRNA with disease progression in persons with CD4(+) cell counts higher than the median (>624 cells/mm(3)) was particularly noteworthy; further variation in the CD4() cell counts within this group was not prognostically significant. Conclusions: The expression of HIV-1 mRNA in peripheral blood mononuclear cells is a strong independent marker for future HIV disease progression, even in persons with normal T-cell subsets.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:02:20