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Titolo:
PERIPHERAL AIRSPACE DIMENSIONS IN PATIENTS WITH COPD
Autore:
BEINERT T; BRAND P; BEHR J; VOGELMEIER C; HEYDER J;
Indirizzi:
GSF FORSCHUNGSZENTRUM UNWELT & GESUNDHEIT GMBH,INST INHALAT BIOL,MARCHIONINISTR 25 D-81377 MUNICH GERMANY GSF FORSCHUNGSZENTRUM UNWELT & GESUNDHEIT GMBH,INST INHALAT BIOL OBERSCHLEISSHEIM GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,PNEUMOL ABT MUNICH GERMANY
Titolo Testata:
Chest
fascicolo: 4, volume: 108, anno: 1995,
pagine: 998 - 1003
SICI:
0012-3692(1995)108:4<998:PADIPW>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIR-SPACE SIZE; FLOW LIMITATION; LUNG-INFLATION; CT; MORPHOMETRY; DEPOSITION; EMPHYSEMA; MODEL;
Keywords:
AEROSOL; AIRSPACE DIMENSIONS; COPD; LUNG; LUNG FUNCTION TEST; QUANTITATIVE HRCT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
T. Beinert et al., "PERIPHERAL AIRSPACE DIMENSIONS IN PATIENTS WITH COPD", Chest, 108(4), 1995, pp. 998-1003

Abstract

Monodisperse aerosol particles can be used to assess noninvasively intrapulmonary airspace dimensions, Since emphysematic changes in the peripheral lung are difficult to detect with most of the common lung function tests, aerosol-derived airway morphometry was used to assess theperipheral airspace dimensions (EAD(800)) in 25 patients with COPD and in 36 healthy volunteers, Spirometric and body plethysmographic measurements were performed in all patients. In ten patients, high-resolution CT-derived mean lung density (MLD) was additionally assessed. In healthy subjects, EAD(800) was 0.39+/-0.05 mm. In patients, EAD(800) was significantly increased (0.82+/-0.33 mm), In a subset of nine patients with severe alpha(1)-antitrypsin deficiency and clinically severe emphysema, EAD(800) was even larger (1.14+/-0.31 mm). In patients, EAD(800) correlated with MLD (r=-0.82), diffusion capacity (DCO) (r=-0.78), and FEV(1) (r=-0.15). Since MLD is considered a valid indicator for lung emphysema, the close correlation between EAD(800) and MLD suggests that EAD(800) reflects enlarged peripheral airspace dimensions in patients with emphysema.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:48:34