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Titolo:
DEMONSTRATION OF ANTIBODIES TO BOVINE DESMOCOLLIN ISOFORMS IN CERTAINPEMPHIGUS SERA
Autore:
DMOCHOWSKI M; HASHIMOTO T; CHIDGEY MAJ; YUE KKM; WILKINSON RW; NISHIKAWA T; GARROD DR;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,CRC,EPITHELIAL MORPHOGENESIS RES GRP,3239 STOPFORD BLDG,OXFORD RD MANCHESTER M13 9PT LANCS ENGLAND UNIV MANCHESTER,SCH BIOL SCI,CRC,EPITHELIAL MORPHOGENESIS RES GRP MANCHESTER M13 9PT LANCS ENGLAND KEIO UNIV,SCH MED,DEPT DERMATOL TOKYO JAPAN
Titolo Testata:
British journal of dermatology
fascicolo: 4, volume: 133, anno: 1995,
pagine: 519 - 525
SICI:
0007-0963(1995)133:4<519:DOATBD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DESMOSOMAL ADHESION MOLECULES; HUMAN-EPIDERMIS; GLYCOPROTEIN-3 DESMOCOLLINS; PARANEOPLASTIC PEMPHIGUS; CYTOPLASMIC DOMAINS; VULGARIS ANTIGEN; CADHERINS; EXPRESSION; IMMUNOFLUORESCENCE; AUTOANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Dmochowski et al., "DEMONSTRATION OF ANTIBODIES TO BOVINE DESMOCOLLIN ISOFORMS IN CERTAINPEMPHIGUS SERA", British journal of dermatology, 133(4), 1995, pp. 519-525

Abstract

We have shown previously that IgG antibodies in certain pemphigus sera, particularly endemic Brazilian pemphigus foliaceus (BPF) sera, react with bovine desmocollins (Dsc), which are transmembranous glycoproteins of desmosome junctions. Desmocollins occur as three different isoforms (Dsc 1, 2 and 3), all of which are represented in the epidermis. In this study, we examined sera of various pemphigus types by immunoblotting purified bovine desmosomes and bovine Dsc 1, 2 and 3 fusion proteins, expressed in pGEX expression vectors. Six of 15 (40.0%) BPF sera, two of 18 (11.1%) non-endemic pemphigus foliaceus sera, eight of 39(20.5%) pemphigus vulgaris (PV) sera, and two of 11 (18.2%) normal sera, showed reactivity with Dsc from desmosomes. Experiments with fusion proteins showed that no Dsc isoform was specifically recognized by sera of any individual pemphigus type. Our results indicate that the pathogenesis of pemphigus might be more complex than previously believed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:43:46