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Titolo:
PROGESTERONE ADMINISTRATION TO OVARIECTOMIZED RATS REDUCES WATER AND SALT INTAKE INDUCED BY CENTRAL ADMINISTRATION OF ANGIOTENSIN-II
Autore:
DOVALE CF; SAAD WA; RENZI A; CAMARGO GMPA; QUEIROZ RC; SILVEIRA JEN; MENANI JV; CAMARGO LAA;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,RUA HUMAITA 1680 BR-14801903 ARARAQUARA SP BRAZIL UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 9, volume: 28, anno: 1995,
pagine: 999 - 1002
SICI:
0100-879X(1995)28:9<999:PATORR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING HORMONE; LUTEINIZING-HORMONE; PITUITARY-GLAND; FEMALE; TESTOSTERONE; SECRETION; INVIVO;
Keywords:
ANGIOTENSIN II; ESTROGEN; PROGESTERONE; TESTOSTERONE; OVARIECTOMY; WATER AND SODIUM INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Dovale et al., "PROGESTERONE ADMINISTRATION TO OVARIECTOMIZED RATS REDUCES WATER AND SALT INTAKE INDUCED BY CENTRAL ADMINISTRATION OF ANGIOTENSIN-II", Brazilian journal of medical and biological research, 28(9), 1995, pp. 999-1002

Abstract

We tested the effects of estradiol, progesterone and testosterone on water and salt intake induced by angiotensin II (ANG II) injected intothe third ventricle of female Holtzman rats weighing 250-300 g. The water and salt ingestion observed after 120 min in the control experiments (injection of 0.5 mu l of 0.15 M NaCl into the third ventricle) was 1.6 +/- 0.3 ml (N = 10) and 0.3 +/- 0.1 ml (N = 8) in intact rats, respectively, and 1.4 +/- 0.3 ml (N = 10) and 0.2 +/- 0.1 (N = 8) in ovariectomized rats, respectively. ANG II injected in intact rats (4, 6,12, 25, and 50 ng, icv, in 0.5 mu l saline) induced an increase in water intake (4.3 +/- 0.6, 5.4 +/- 0.7. 7.8 +/- 0.8, 10.4 +/- 1.2, 11.2 /- 1.4 ml/120 min, respectively) (N = 43). The same doses of icv ANG II in intact rats increased the 3% NaCl intake (0.9 +/- 0.2; 1.4 +/- 0.3, 2.3 +/- 0.4, 2.2 +/- 0.3. and 2.5 +/- 0.4 ml/120 min, respectively) (N = 42). When administered to ovariectomized rats ANG II induced comparable amounts of water intake (4.0 +/- 0.5, 4.8 +/- 0.6, 6.9 +/- 0.7. 9.6 +/- 0.8, and 10.9 +/- 1.2 ml/120 min, respectively) (N = 43) but there was a significant decrease of 3% NaCl solution ingestion (0.3 /- 0.1, 0.4 +/- 0.1, 0.8 +/- 0.2, 0.7 +/- 0.2, and 0.6 +/- 0.2 ml/120min, respectively) (N = 44). Estrogen (50 mu g), progesterone (25 ng), and testosterone (300 mu g) were injected daily into ovariectomized rats for 21 days. Treatment with estrogen decreased the water intake and abolished the saline ingestion induced by icy injection of ANG II (12 ng (2.8 +/- 1.2 and 0.3 +/- 0.1 ml/120 min, respectively) (N = 8). Treatment with progesterone also reduced the water intake (3.3 +/- 0.6ml/120 min) (N = 8) and abolished the ANG II-induced saline ingestion(0.4 +/- 0.1 ml/120 min) (N = 8), but these effects were not observedwith testosterone (6.4 +/- 0.8 and 2.2 +/- 0.3 ml/120 min, respectively) (N = 8). These results indicate that ANG II induces a greater increase in sodium intake in intact female rats than in ovariectomized rats and that estrogen and progesterone impair water and sodium intake inovariectomized rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:00:56