Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ISOLATION OF A NONSTEROIDAL CONTRAGESTATIVE AGENT FROM SRI-LANKAN MARINE RED-ALGA, GELIDIELLA-ACEROSA
Autore:
PREMAKUMARA GAS; RATNASOORIYA WD; TILLEKERATNE LMV;
Indirizzi:
UNIV COLOMBO,DEPT ZOOL,POB 1490 COLOMBO 3 SRI LANKA UNIV COLOMBO,DEPT ZOOL COLOMBO 3 SRI LANKA UNIV COLOMBO,DEPT CHEM COLOMBO 3 SRI LANKA
Titolo Testata:
Contraception
fascicolo: 6, volume: 54, anno: 1996,
pagine: 379 - 383
SICI:
0010-7824(1996)54:6<379:IOANCA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Keywords:
RED ALGAE; GELIDIELLA ACEROSA; POST-COITAL CONTRACEPTIVES; FERTILITY; ANTIPROGESTERONE; SPHINGOSINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
G.A.S. Premakumara et al., "ISOLATION OF A NONSTEROIDAL CONTRAGESTATIVE AGENT FROM SRI-LANKAN MARINE RED-ALGA, GELIDIELLA-ACEROSA", Contraception, 54(6), 1996, pp. 379-383

Abstract

This study reports the isolation of a non-steroidal contragestative agent from the Sri Lankan marine red alga, Gelidiella acerosa. One-hundred grams of MeOH-CH2Cl2 (1:1) crude extract of G. acerosa was initially partitioned into hexane, CH2Cl2 and EtOAc, respectively, using the modified Kupchan scheme. At each separation step, all the resulting fractions were tested for contragestative effects in pregnant rats. The fertility was assessed in terms of the number of viable implants following oral administration of fractions (co-precipitated with polyvinylpyrrolidone), on day 1 through day 7 of pregnancy. The hexane fraction with highest activity was subjected to gel filtration through SephadexLH-20, vacuum liquid chromatography over TLC-grade silica, two open-column chromatography runs over silica gel (60-120 mesh), and HPLC to isolate the active component. Nuclear magnetic resonance and infrared spectroscopic analysis revealed that the contragestative agent of G. acerosa is a sphingosine derivative. (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:13:01