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Titolo:
AN IMMUNOHISTOCHEMICAL STUDY OF NEUROACTIVE SUBSTANCES IN THE SKIN OFATOPIC-DERMATITIS
Autore:
JOHANSSON O; LIU PY; HAN SW; LINDBERGER M; LJUNGDAHL A; WAHLGREN CF;
Indirizzi:
KAROLINSKA INST,DEPT NEUROSCI,EXPTL DERMATOL UNIT S-17177 STOCKHOLM SWEDEN HUDDINGE HOSP,DEPT NEUROL S-14186 HUDDINGE SWEDEN KAROLINSKA HOSP,DEPT DERMATOL S-17176 STOCKHOLM SWEDEN
Titolo Testata:
EJD. European journal of dermatology
fascicolo: 6, volume: 5, anno: 1995,
pagine: 516 - 523
SICI:
1167-1122(1995)5:6<516:AISONS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL PEPTIDE; PERIVASCULAR DENDRITIC CELL; THY-1+ EPIDERMAL-CELLS; LYMPHOCYTE-T SUBSETS; LANGERHANS CELLS; MONOCLONAL-ANTIBODIES; URTICARIA-PIGMENTOSA; NEUROPEPTIDE-Y; SOMATOSTATIN; INNERVATION;
Keywords:
ATOPIC DERMATITIS; NEUROPEPTIDES; IMMUNOHISTOCHEMISTRY; SOMATOSTATIN; NPY; CGRP; CCK; EPIDERMAL DENDRITIC CELL; NERVE FIBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
O. Johansson et al., "AN IMMUNOHISTOCHEMICAL STUDY OF NEUROACTIVE SUBSTANCES IN THE SKIN OFATOPIC-DERMATITIS", EJD. European journal of dermatology, 5(6), 1995, pp. 516-523

Abstract

The occurrence of certain neuropeptides and other neuroactive substances in atopic dermatitis (AD) was investigated in the involved and uninvolved skin from fifteen patients, as compared with normal skin from six healthy volunteers, using immunohistochemistry. Antibodies to neuropeptide tyrosine (NPY), calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), somatostatin (SOM), peptide histidine isoleucine amide (PHI), vasoactive intestinal polypeptide (VIP), protein S-100 (S-100), protein gene product 9.5 (PGP 9.5) and neuron-specific enolase (NSE) were used. The distributional patterns of SOM immunoreactive (SOM(+)) epidermal and dermal cells in involved and uninvolved skin of AD patients ranged considerably without any clear correlation with the clinical eczema score or the serum IgE level. The range of patterns could be described as follows: In seemingly uninvolved skin, SOM cells were found only around blood vessels. The next stage in the range showed the SOM epidermal cells without dendrites in the basal layer, forming one line. Then, in the next stage, these SOM(+) epidermal cells in the basal layer were irregularly arranged with short dendrites. In the clinically involved skin SOM(+) epidermal cells appeared in the suprabasallayer as well as in the basal layer. The SOM(+) cells in the basal layer then had longer dendrites and a few cells were present at the dermoepidermal junction. In contrast to the suprabasal epidermal cells which were decreased In number, many round or oval SOM cells were gathered in the papillary dermis near the dermoepidermal junction. The SOM(+)cells around the blood vessels showed a scattered arrangement rather than a densely packed one. In the next stage of the range, the spindle-shaped SOM(+) cells were more Predominant than the round-or oval shaped eel Is In the dermis. Finally, in the last stage Of the disease range, there were no SOM epidermal cells and in the few round, oval or spindle-shaped SOM(+) cells were seen, either located perivascularly or freely in the dermis, or only around blood vessels. NPY CGRP, CCK and PHI immunoreactive epidermal dendritic cells were also observed in involved skin of twelve, eight, eleven and two AD patients, respectively,but without any clear pattern. No NPY, CGRP, CCK or PHI immunoreactive epidermal dendritic cells were found in normal control skin. NPY, CGRP and PHI immunoreactive nerve fibers were seen in both groups, however, there were no differences between them. The patterns of structuralmarkers, such as S-100 PGP 9.5 and NSE including positive nerve fibers, did not differ between the patients and the healthy controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:08:58