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Titolo:
ASSESSMENT OF THE MIXED DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL INA 3-CHOICE ETHANOL-DIZOCILPINE-WATER DISCRIMINATION IN RATS
Autore:
GATTO GJ; BOWEN CA; GRANT KA;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PHYSIOL & PHARMACOL,MED CTRBLVD WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT COMPARAT MED WINSTON SALEM NC 27157
Titolo Testata:
Behavioural pharmacology
fascicolo: 5-6, volume: 6, anno: 1995,
pagine: 601 - 613
SICI:
0955-8810(1995)6:5-6<601:AOTMDS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; NMDA RECEPTOR; ANTAGONISTS; INHIBITION; MK-801; PHENCYCLIDINE; SUBSTITUTION; INVOLVEMENT; AMPHETAMINE; RESPONSES;
Keywords:
DIZOCILPINE; ETHANOL; NMDA; PENTOBARBITAL; RAT; RU 24969; 3-CHOICE DRUG DISCRIMINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Gatto et al., "ASSESSMENT OF THE MIXED DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL INA 3-CHOICE ETHANOL-DIZOCILPINE-WATER DISCRIMINATION IN RATS", Behavioural pharmacology, 6(5-6), 1995, pp. 601-613

Abstract

Previous drug discrimination studies have elucidated the importance of the NMDA, GABA(A) and 5-HT1 receptor systems in mediating the discriminative stimulus effects of ethanol. The present study used a three-choice drug discrimination paradigm in an attempt to determine whether the salient NMDA antagonistic effects were separable from other stimulus effects of ethanol. Adult Long-Evans rats (n = 7) were trained to discriminate ethanol (1.5 g/kg, intragastric (i.g.)), the uncompetitiveNMDA antagonist dizocilpine (0.17 mg/kg, i.g.) or water (3.5 ml, i.g.) under a food-reinforced fixed-ratio 15 (FR15) schedule of reinforcement. Following training, substitution tests were conducted with the GABA(A)/benzodiazepine (GABA(A)/BDZ) positive modulator pentobarbital (PB, 5.6-17 mg/kg, i.g.), the uncompetitive NMDA antagonist phencyclidine (PCP, 0.1-5.6 mg/kg, i.p.) and the 5-HT1 agonist RU 24969 (0.1-3.0 mg/kg, i.p.). Complete substitution of PCP (ED(50), 0.9 mg/kg) for dizocilpine was found in all animals. Conversely, PB (ED(50), 10 mg/kg) substituted fully for ethanol in five of seven animals, whereas RU 24969(ED(50), 1.4 mg/kg) completely substituted for ethanol in only three of seven animals tested. The results demonstrate that a three-choice discrimination using dizocilpine, ethanol and water as training conditions can be established in rats. By contrasting the discriminative stimulus effects of an uncompetitive NMDA antagonist to ethanol, the ethanol-like effects of pentobarbital and RU 24969 are attenuated compared to previous studies of two-choice ethanol water discrimination.

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Documento generato il 02/12/20 alle ore 14:30:02