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Titolo:
MODULATION OF LEARNING-PROCESSES BY IONOTROPIC GLUTAMATE-RECEPTOR LIGANDS
Autore:
DANYSZ W; ZAJACZKOWSKI W; PARSONS CG;
Indirizzi:
MERZ & CO,DEPT PHARMACOL,POB 111353 D-60318 FRANKFURT GERMANY
Titolo Testata:
Behavioural pharmacology
fascicolo: 5-6, volume: 6, anno: 1995,
pagine: 455 - 474
SICI:
0955-8810(1995)6:5-6<455:MOLBIG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; D-ASPARTATE RECEPTOR; EXCITATORY AMINO-ACIDS; NMDA ANTAGONISTS CPP; RADIAL ARM MAZE; ALZHEIMERS-DISEASE; D-CYCLOSERINE; WORKING MEMORY; SYNAPTIC PLASTICITY; SPATIAL MEMORY;
Keywords:
AGONISTS; AMPA RECEPTORS; ANTAGONISTS; LEARNING; LONG-TERM POTENTIATION; MEMORY; NMDA RECEPTORS; POSITIVE MODULATORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
188
Recensione:
Indirizzi per estratti:
Citazione:
W. Danysz et al., "MODULATION OF LEARNING-PROCESSES BY IONOTROPIC GLUTAMATE-RECEPTOR LIGANDS", Behavioural pharmacology, 6(5-6), 1995, pp. 455-474

Abstract

A great body of evidence has been provided for the role of N-methyl-D-aspartate (NMDA) receptors in learning processes, since the pioneering work of Morris et al. (1986) showing impairment of water maze learning and long-term potentiation (LTP) during i.c.v, infusion of the NMDAreceptor antagonst 2-amino-5-phosphonovaleric acid (AP5). The existing literature, based on pharmacological studies, suggests the importance of NMDA receptors for the acquisition and/or the initial phase of long-term memory consolidation in many, but not all, learning paradigms. Data on short-term memory are inconsistent, probably due to difficulties in separation of learning deficits from performance. Although it is generally accepted that NMDA receptor antagonists impair learning, more recent data suggest that, under certain conditions, the opposite effect, enhancement of learning, can be obtained. The role of pha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors in learning, although accepted in LTP, is less well documented. It has been suggested that positive modulation of these receptors could result in cognitive enhancement that might find therapeutic application. The present paper reviews the literature dealing with these issues and discusses possible consequences for the therapy of dementia.

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Documento generato il 28/03/20 alle ore 22:13:16