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Titolo:
THE EFFECTS OF INHALED BECLOMETHASONE DIPROPIONATE ON LUNG-FUNCTION AND HISTAMINE RESPONSIVENESS IN RECURRENTLY WHEEZY INFANTS
Autore:
STICK SM; BURTON PR; CLOUGH JB; COX M; LESOUEF PN; SLY PD;
Indirizzi:
PRINCESS MARGARET HOSP CHILDREN,DEPT RESP MED,POB D184 PERTH WA 6001 AUSTRALIA CHILDRENS HOSP,MED CTR,INST CHILD HLTH RES PERTH WA AUSTRALIA
Titolo Testata:
Archives of Disease in Childhood
fascicolo: 4, volume: 73, anno: 1995,
pagine: 327 - 332
SICI:
0003-9888(1995)73:4<327:TEOIBD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG DELIVERY; BUDESONIDE; SALBUTAMOL; CHILDREN; BRONCHITIS; AGE;
Keywords:
WHEEZY INFANTS; INHALED STEROIDS; LUNG FUNCTION; BRONCHIAL RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Stick et al., "THE EFFECTS OF INHALED BECLOMETHASONE DIPROPIONATE ON LUNG-FUNCTION AND HISTAMINE RESPONSIVENESS IN RECURRENTLY WHEEZY INFANTS", Archives of Disease in Childhood, 73(4), 1995, pp. 327-332

Abstract

Inhaled steroids improve pulmonary function and bronchial responsiveness in older asthmatics. Data from studies using subjective outcome measures to determine the effectiveness of inhaled steroids in infants with recurrent wheezing are equivocal. Therefore, this study tested thehypothesis that beclomethasone dipropionate improves pulmonary function, including bronchial responsiveness to histamine, in recurrently wheezy infants The study was double blind, placebo controlled lasting nine weeks. After the first baseline week, pulmonary function was measured using the rapid thoraco-abdominal compression technique and bronchial responsiveness assessed with a histamine challenge test. Infants were then randomly allocated to receive doses of placebo or beclomethasone dipropionate (100 mu g/puff) from metered aerosols. Two puffs of test aerosol were administered twice daily for eight weeks via a large volume spacer fitted with a facemask. Symptoms were recorded daily and pulmonary function and bronchial responsiveness assessed at the end ofthe treatment period; 50 infants, median age 12 months (range 5 to 18months), were recruited. Twenty three in the beclomethasone dipropionate group and 15 in the placebo group completed the study and had pairs of pulmonary function measurements. Three were probable treatment failures (one beclomethasone dipropionate, two placebo), three were possible treatment failures (placebo), and others were non-compliant with study protocol. Baseline variables were not significantly different between those infants who completed the study and those who did not. Beclomethasone dipropionate and placebo groups were similar in all respects at baseline. Lung function and improved for both groups during the study. Bronchial responsiveness increased significantly in the placebogroup but there were no statistically significant differences betweengroups for any of the other outcome measures. It is concluded that beclomethasone dipropionate (400 mu g daily) via a large volume spacer does not significantly improve lung function or symptoms in recurrentlywheezy infants symptoms of infants but might have a beneficial effecton bronchial responsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 15:50:19