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Titolo:
THE ROLE OF VINDESINE IN ONCOLOGY - RECOMMENDATIONS AFTER 10 YEARS EXPERIENCE
Autore:
DANCEY J; STEWARD WP;
Indirizzi:
QUEENS UNIV,NCIC,CLIN TRIALS GRP,82-84 BARRIE ST KINGSTON ON K7L 4B4 CANADA QUEENS UNIV,NCIC,CLIN TRIALS GRP KINGSTON ON K7L 4B4 CANADA
Titolo Testata:
Anti-cancer drugs
fascicolo: 5, volume: 6, anno: 1995,
pagine: 625 - 636
SICI:
0959-4973(1995)6:5<625:TROVIO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LUNG-CANCER; PHASE-II TRIAL; ADVANCED BREAST-CANCER; ACUTE LYMPHOBLASTIC-LEUKEMIA; ADVANCED MALIGNANT-MELANOMA; ACUTE LYMPHOCYTIC-LEUKEMIA; CISPLATIN PLUS VINDESINE; NON-HODGKINS-LYMPHOMA; RANDOMIZED TRIAL; MITOMYCIN-C;
Keywords:
CHEMOTHERAPY; LEUKEMIA; LUNG CANCER; LYMPHOMA; MELANOMA; VINDESINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
122
Recensione:
Indirizzi per estratti:
Citazione:
J. Dancey e W.P. Steward, "THE ROLE OF VINDESINE IN ONCOLOGY - RECOMMENDATIONS AFTER 10 YEARS EXPERIENCE", Anti-cancer drugs, 6(5), 1995, pp. 625-636

Abstract

Vindesine, a vinca alkaloid derived from vinblastine, has been examined for activity against a variety of solid and hematological malignancies. Single-agent response rates average 18% in non-small cell lung cancer and it has been widely used in combination with cisplatin as first-line therapy for this disease. It has limited activity in breast cancer (average 16% response rate) and does not appear to improve outcomewhen combined with anthracyclines. Vindesine is frequently incorporated into combination regimens for the treatment of malignant melanoma, and head and neck cancer, although its single-agent activity in these diseases is modest (average 14 and 12% response rates, respectively). Its activity in the hematological malignancies appears to be greater and it has an important role in the treatment of acute lymphoblastic leukemia, particularly in children. It is currently being examined for its potential to synergize with the interferons and for its value as prolonged therapy in preventing metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:15:01