Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INFLUENZA-VIRUSES, CELL ENZYMES, AND PATHOGENICITY
Autore:
ROTT R; KLENK HD; NAGAI Y; TASHIRO M;
Indirizzi:
UNIV GIESSEN,INST VIROL,FRANKFURTER STR 107 D-35392 GIESSEN GERMANY UNIV MARBURG,INST VIROL W-3550 MARBURG GERMANY UNIV TOKYO,DEPT VIRAL INFECT TOKYO JAPAN NATL INST HLTH,DEPT VIROL 1 TOKYO 141 JAPAN
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 4, volume: 152, anno: 1995, supplemento:, S
pagine: 16 - 19
SICI:
1073-449X(1995)152:4<16:ICEAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLEAVAGE SITE; CHICK-EMBRYO; SENDAI VIRUS; PROTEOLYTIC ACTIVATION; FACTOR-X; A VIRUS; HEMAGGLUTININ; PROTEASE; DETERMINANT; PNEUMONIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
R. Rott et al., "INFLUENZA-VIRUSES, CELL ENZYMES, AND PATHOGENICITY", American journal of respiratory and critical care medicine, 152(4), 1995, pp. 16-19

Abstract

Proteolytic cleavage of the influenza virus hemagglutinin glycoprotein (HA) by cellular proteases is a prerequisite for virus infectivity, spread of the virus in the infected organism, tissue tropism, and viral pathogenicity. Production of infectious virus depends upon the structure at the HA cleavage site as well as the substrate specificity and the distribution of appropriate enzymes. Differences exist in the specificities of the endoproteases that recognize the different sequence motifs at the cleavage site. With avian influenza viruses that cause lethal systemic infections, the cleavage site consists of multi-basic amino acids. Furin, which activates this type of HA, is a member of the subtilisin family and represents the prototype of ubiquitously occurring membrane-bound proteases. On the other hand, serine proteases secreted from a restricted number of cell types and some bacterial enzymes recognize a monobasic cleavage signal at HA of the mammalian and the apathogenic avian influenza viruses. The limited occurrence of these proteases results in only localized infection. Implementation of these defined conditions for virus activation may represent a novel type of disease control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:09:12