Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACUTE EFFECTS OF GLUCOSE ON REACTIVITY OF CEREBRAL MICROCIRCULATION -ROLE OF ACTIVATION OF PROTEIN-KINASE-C
Autore:
MAYHAN WG; PATEL KP;
Indirizzi:
UNIV NEBRASKA,MED CTR,DEPT PHYSIOL & BIOPHYS,600 S 42ND ST OMAHA NE 68198
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 4, volume: 38, anno: 1995,
pagine: 1297 - 1302
SICI:
0363-6135(1995)38:4<1297:AEOGOR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATATION; DIABETES-MELLITUS; ELEVATED GLUCOSE; ADENOSINE 5'-DIPHOSPHATE; BASILAR ARTERY; ARTERIOLES; IMPAIRMENT; RELAXATION; RESPONSES; BRAIN;
Keywords:
ADENOSINE DIPHOSPHATE; ACETYLCHOLINE; NITROGLYCERIN BRAIN; N-METHYL-D-ASPARTATE; HISTAMINE; ENDOTHELIUM-DEPENDENT DILATION; RATS; HYPERGLYCEMIA; CALPHOSTIN C; CHELERYTHRINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
W.G. Mayhan e K.P. Patel, "ACUTE EFFECTS OF GLUCOSE ON REACTIVITY OF CEREBRAL MICROCIRCULATION -ROLE OF ACTIVATION OF PROTEIN-KINASE-C", American journal of physiology. Heart and circulatory physiology, 38(4), 1995, pp. 1297-1302

Abstract

Our first goal was to determine whether acute hyperglycemia alters endothelium-dependent reactivity of rat cerebral arterioles. Our second goal was to investigate a possible mechanism for impaired reactivity during acute hyperglycemia. Diameter of pial arterioles was measured during suffusion with ADP, acetylcholine, histamine, N-methyl-D-aspartate (NMDA), and nitroglycerin before and during application of a suffusate containing D-glucose (5, 10, 20, and 25 mM). ADP, acetylcholine, histamine, NMDA, and nitroglycerin produced dose-related vasodilatation before application of D-glucose. Vasodilatation in response to the agonists was not altered by 5 and 10 mM D-glucose. In contrast, vasodilatation in response to ADP, acetylcholine, histamine, and NMDA was impaired during application of 20 and 25 mM D-glucose. Dilatation in response to nitroglycerin was not altered. Application of the protein kinaseC inhibitor calphostin C (1.0 nM) or chelerythrine (10 nM) restored endothelium-dependent vasodilatation during application of 25 mM D-glucose. Thus acute hyperglycemia impairs endothelium-dependent responses of cerebral arterioles via the activation of protein kinase C.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:53:52