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Titolo:
ANALYSIS OF EVOKED AND SPONTANEOUS QUANTAL RELEASE AT HIGH-PRESSURE IN CRUSTACEAN EXCITATORY SYNAPSES
Autore:
GOLAN H; COLTON JS; MOORE HJ; GROSSMAN Y;
Indirizzi:
BEN GURION UNIV NEGEV,FAC HLTH SCI,COROB CTR MED RES,DEPT PHYSIOL IL-84105 BEER SHEVA ISRAEL BEN GURION UNIV NEGEV,FAC HLTH SCI,COROB CTR MED RES,DEPT PHYSIOL IL-84105 BEER SHEVA ISRAEL USN,MED RES INST,HIGH PRESSURE MOLEC & CELLULAR NEUROBIOL GRP BETHESDA MD 20889
Titolo Testata:
Pflugers Archiv
fascicolo: 5, volume: 430, anno: 1995,
pagine: 617 - 625
SICI:
0031-6768(1995)430:5<617:AOEASQ>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROMUSCULAR-JUNCTION; HYDROSTATIC-PRESSURE; NEUROTRANSMITTER RELEASE; NERVE-TERMINALS; CRAYFISH MUSCLE; TRANSMITTER; AXON; DIFFERENTIATION; MODULATION; CONDUCTION;
Keywords:
GLUTAMATERGIC SYNAPSES; BINOMIAL AND POISSON-TYPE RELEASE; MINIATURE SYNAPTIC CURRENTS; GIANT MINIATURE EXCITATORY POSTSYNAPTIC CURRENTS; HYPERBARIC CONDITIONS; NEUROMUSCULAR JUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
H. Golan et al., "ANALYSIS OF EVOKED AND SPONTANEOUS QUANTAL RELEASE AT HIGH-PRESSURE IN CRUSTACEAN EXCITATORY SYNAPSES", Pflugers Archiv, 430(5), 1995, pp. 617-625

Abstract

The cellular mechanisms underlying the effect of high pressure on synaptic transmission were studied in the opener muscle of the lobster walking leg. Excitatory postsynaptic currents (EPSCs) were recorded using a loose macropatch-clamp technique at normal pressure and 3.5, 6.9 MPa helium pressure. Responses of the single excitatory axon could be grouped into two types: low-yield (L) synapses exhibiting small EPSCs with a considerable number of failures, and high-yield (H) synapses having larger EPSCs with very few failures. High pressure reduced the average EPSC amplitude in all synapses and shifted their amplitude histograms to the left by decreasing the quantal content (m) without changing their quantum current (q). A binomial distribution fit of EPSC amplitudes revealed that high pressure greatly decreased n, the number of available active zones, but the effect on p, the probability of releasefor each zone, was not consistent. Many of the spontaneous miniature EPSCs (mEPSCs), observed only in L-type synapses, were ''giant'' (size= 2-5 q). High pressure increased the frequency of the giant mEPSCs but had little effect on their amplitude histogram. High pressure depressed evoked synaptic transmission by modulating the presynaptic quantal release parameters, but concomitantly enhanced spontaneous quantal release by an unknown mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:37:43