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Titolo:
MELANOMA-92 - AN EPIDEMIOLOGIC-STUDY OF U VEAL MELANOMA IN FRANCE
Autore:
VIDAL JL; BACIN F; ALBUISSON E; ROZAN R; DESJARDINS L; DHERMIES F; GRANGE JD; CHAUVEL P; CAUJOLLE JP; SAHEL J; DIALLOROSIER L;
Indirizzi:
HOP GABRIEL MONTPIED,SERV OPHTALMOL,BP N 69 F-63003 CLERMONT FERRAND FRANCE
Titolo Testata:
Journal francais d'ophtalmologie
fascicolo: 8-9, volume: 18, anno: 1995,
pagine: 520 - 528
SICI:
0181-5512(1995)18:8-9<520:M-AEOU>2.0.ZU;2-C
Fonte:
ISI
Lingua:
FRE
Keywords:
UVEAL MELANOMA; EPIDEMIOLOGY; TUMOR; METASTASES; TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Vidal et al., "MELANOMA-92 - AN EPIDEMIOLOGIC-STUDY OF U VEAL MELANOMA IN FRANCE", Journal francais d'ophtalmologie, 18(8-9), 1995, pp. 520-528

Abstract

Purpose The purposes of this study were to evaluate the incidence of uveal melanoma in France in 1992, to describe the characteristics of the tumors in their treatments. Methods This was a retrospective and multicentric study. First a questionnaire was sent to 4 575 French ophthalmologists asking whether they had established a diagnosis of uveal melanoma during 1992, and if so, to describe the tumor and its management. Then the patients files were reviewed in the specialized treatmentcenter (Paris, Lyon, Nice, Strasbourg, Bordeaux, Clermont-Ferrand). All the data were statistically analysed. Results 412 new cases of uveal melanomas were registered (incidence 0.7/100 000) affecting 234 females and 178 males. The cases ranged in age from 7 to 93 years (mean 61.5 years). There were 5 (1 %) isolated tumors of the iris, 75 (18 %) of the ciliary body, either isolated (10 %) either associated to iris and/or to choroidal tumors and 332 (81 %) choroidal melanomas. 201 (53 %) tumors were posterior to the equator and 153 (40 %) had a margin atless than 3 mm of the optic disc; 87 (21 %) melanomas were detected in asymptomatic patients. In 29 (7 %) other cases, the diagnosis was established after enlargement of the tumor. In all other eyes, symptoms were present. 17 % of the melanomas were T-1 34 % were T-2 et 48 % were T-3. 353 (86 %) melanomas were pigmented 30 (7 %) were achromic and 29 (7 %) of the mixed color type. 156 (38 %) tumors were associated with a retinal detachment. In 12 cases (3 %), at presentation there was an extrascleral extension. 9 patients (2 %) had metastases (7 to the liver, 1 to the lungs and 1 to the lungs and bones). The study of the patients residence and work did not show any environmental risk factor. The initial treatment wa protontherapy in 251 patients (63 %), plaquetherapy in 91 (23 %), enucleation in 40 (10 %), and other methods in 18. Conclusion This was the first epidemiologic study conducted in France on this subject. It describes the clinical features of the disease, its geographical display and its management in this country.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:37:42