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Titolo:
ATTOMOLE-SENSITIVITY ELECTROSPRAY SOURCE FOR LARGE-MOLECULE MASS-SPECTROMETRY
Autore:
VALASKOVIC GA; KELLEHER NL; LITTLE DP; AASERUD DJ; MCLAFFERTY FW;
Indirizzi:
CORNELL UNIV,BAKER LAB CHEM ITHACA NY 14853 CORNELL UNIV,BAKER LAB CHEM ITHACA NY 14853
Titolo Testata:
Analytical chemistry
fascicolo: 20, volume: 67, anno: 1995,
pagine: 3802 - 3805
SICI:
0003-2700(1995)67:20<3802:AESFLM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE BIOMOLECULES; IONIZATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Valaskovic et al., "ATTOMOLE-SENSITIVITY ELECTROSPRAY SOURCE FOR LARGE-MOLECULE MASS-SPECTROMETRY", Analytical chemistry, 67(20), 1995, pp. 3802-3805

Abstract

Full mass spectra of high resolving power are obtained from 0.2 nL sample volumes of large (>10 kDa) nucleotides and proteins using a new electrospray ionization (ESI) system combined with Fourier transform mass spectrometry. The ESI needles are fabricated by laser-heated pulling of fused-silica tubing (5-20 mu m i.d.), followed by chemical etching and surface metalization. Total analyte loaded at the instrument of 8.6 fmol and 216 amol produces signal-to-noise ratios of 400:1 and 60:1, respectively, and resolving power of >10(5) for full mass spectra, while the total amount of material consumed is similar to 150 and 10 amol, respectively.

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Documento generato il 07/08/20 alle ore 20:42:01