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Titolo:
EFFECT OF CHRONIC INFUSION OF PLACENTAL-LACTOGEN ON OVINE FETAL GROWTH IN LATE-GESTATION
Autore:
SCHOKNECHT PA; MCGUIRE MA; COHICK WS; CURRIE WB; BELL AW;
Indirizzi:
CORNELL UNIV,DEPT ANIM SCI,262 MORRISON HALL ITHACA NY 14853 CORNELL UNIV,DEPT ANIM SCI ITHACA NY 14853 UNIV N CAROLINA,SCH MED,DIV ENDOCRINOL CHAPEL HILL NC 27599
Titolo Testata:
Domestic animal endocrinology
fascicolo: 6, volume: 13, anno: 1996,
pagine: 519 - 528
SICI:
0739-7240(1996)13:6<519:EOCIOP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEAT-STRESS; CHORIONIC SOMATOMAMMOTROPIN; PRENATAL DEVELOPMENT; BINDING-PROTEINS; ADIPOSE-TISSUE; INSULIN; HORMONE; SHEEP; FIBROBLASTS; LAMB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Schoknecht et al., "EFFECT OF CHRONIC INFUSION OF PLACENTAL-LACTOGEN ON OVINE FETAL GROWTH IN LATE-GESTATION", Domestic animal endocrinology, 13(6), 1996, pp. 519-528

Abstract

To test the hypothesis that placental lactogen (PL) is a humoral regulator of fetal growth, six singleton sheep fetuses received a continuous intravenous fusion of 1.2 mg/d of purified ovine PL (oPL) for 14 d,beginning on Day 122 of gestation. The plasma concentration of oPL was approximately four-fold higher in infused fetuses than in six control fetuses that received a continuous infusion of saline. The circulating insulin-like growth factor 1 (IGF-I) concentration was also significantly elevated in PL-infused fetuses (43.1 +/- 1.7 vs. 31.9 +/- 4.1 ng/ml; P < 0.05). Animals were slaughtered on Day 136, and the placentaand all major fetal tissues were dissected, weighed, and subsampled for chemical analysis. Fetal weight and crown-rump length were not significantly affected by treatment; however, the aggregate weight of the brain, liver, lungs, and heart tended to be larger (85.3 +/- 2.1 vs. 79.9 +/- 1.5 g/kg fetus; mean +/- SE, P = 0.07) and the thyroid gland was smaller (0.18 +/- 0.1 vs. 0.26 +/- 0.02 g/kg fetus; P < 0.05) in the PL-infused fetuses. The livers of the PL-infused fetuses had also accumulated additional glycogen (13.1 +/- 1.7 vs. 8.4 +/- 0.7 g; P < 0.05). In late gestation, PL within the fetal compartment increases fetalplasma IGF-I concentration and hepatic glycogen deposition and may affect the growth of several vital organs. (C) Elsevier Science Inc. 1996

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 11:44:25