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Titolo:
COMPARATIVE DISTRIBUTION OF RECEPTORS FOR AMYLIN AND THE RELATED PEPTIDES CALCITONIN-GENE-RELATED PEPTIDE AND CALCITONIN IN RAT AND MONKEY BRAIN
Autore:
CHRISTOPOULOS G; PAXINOS G; HUANG XF; BEAUMONT K; TOGA AW; SEXTON PM;
Indirizzi:
ST VINCENTS INST MED RES,41 VICTORIA PARADE FITZROY VIC 3065 AUSTRALIA ST VINCENTS INST MED RES FITZROY VIC 3065 AUSTRALIA UNIV NEW S WALES,SCH PSYCHOL KENSINGTON NSW 2033 AUSTRALIA AMYLIN PHARMACEUT INC SAN DIEGO CA 92121 UNIV CALIF LOS ANGELES,DEPT NEUROL LOS ANGELES CA 90024
Titolo Testata:
Canadian journal of physiology and pharmacology
fascicolo: 7, volume: 73, anno: 1995,
pagine: 1037 - 1041
SICI:
0008-4212(1995)73:7<1037:CDORFA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; BINDING-SITES; SALMON-CALCITONIN; LOCALIZATION; AUTORADIOGRAPHY;
Keywords:
AMYLIN; CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; RECEPTOR; RAT; MONKEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
G. Christopoulos et al., "COMPARATIVE DISTRIBUTION OF RECEPTORS FOR AMYLIN AND THE RELATED PEPTIDES CALCITONIN-GENE-RELATED PEPTIDE AND CALCITONIN IN RAT AND MONKEY BRAIN", Canadian journal of physiology and pharmacology, 73(7), 1995, pp. 1037-1041

Abstract

The distribution of amylin receptors (I-125-labelled rat amylin) in brains of rat and monkey were mapped and compared with the distributionof receptors for calcitonin (CT) (I-125-labelled salmon CT) and calcitonin gene related peptide (CGRP) (rat, I-125-labelled rat CGRP alpha;monkey, I-125-labelled human CGRP alpha). In rat, amylin receptors were discretely distributed with the highest receptor densities found inmid-caudal accumbens nucleus, parts of the bed nucleus of the stria terminalis, amygdala, and hypothalamus. Moderate to high densities of binding also occurred in the area postrema, subfornical organ, vascularorgan of the lamina terminalis, locus ceruleus, dorsal raphe, and caudal solitary tract nucleus. In monkey, the distribution of amylin binding sites was similar, although the highest densities of receptors were in the hypothalamus, with relatively fewer sites present in the accumbens nucleus. In rat, the distribution of amylin receptors formed a subset of the receptor distributions for I-125-labelled salmon CT and I-125-labelled rat CGRP alpha. In contrast, in monkey, although the amylin receptors again formed a subset of the binding sites identified with I-125-labelled salmon CT, there was very little overlap with the pattern of CGRP receptor distribution. This suggests that the specificity profile of amylin receptors in primates differs from that of amylin receptors in the rat, with CGRP alpha having relatively lower affinityfor the primate amylin receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:43:40