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Titolo:
EFFECTS OF GONADAL ANDROGENS AND ESTROGENS ON ADRENAL ANDROGEN LEVELS
Autore:
POLDERMAN KH; GOOREN LJG; VANDERVEEN EA;
Indirizzi:
FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED,DIV ENDOCRINOL,POB 7057 1007 MB AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT INTERNAL MED,DIV ENDOCRINOL 1007 MB AMSTERDAM NETHERLANDS
Titolo Testata:
Clinical endocrinology
fascicolo: 4, volume: 43, anno: 1995,
pagine: 415 - 421
SICI:
0300-0664(1995)43:4<415:EOGAAE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROEPIANDROSTERONE SULFATE; INSULIN RESISTANCE; DEHYDROISOANDROSTERONE SULFATE; SEX-DIFFERENCES; NORMAL WOMEN; STEROIDOGENESIS; TESTOSTERONE; FETAL; PLASMA; CHOLESTEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Polderman et al., "EFFECTS OF GONADAL ANDROGENS AND ESTROGENS ON ADRENAL ANDROGEN LEVELS", Clinical endocrinology, 43(4), 1995, pp. 415-421

Abstract

OBJECTIVE The physiological role of adrenal androgens in humans remains unclear. Furthermore, there are few data on the relation between sex steroids and adrenal androgen production. We have assessed the effects of sex steroid hormone administration on adrenal androgen levels, by studying a large group of transsexual patients. DESIGN A non-randomized intervention. SETTING A university teaching hospital. PATIENTS Thirty-one male-to-female and 22 female-to-male transsexual patients.MEASUREMENTS Plasma levels of adrenal androgens were measured in a group of male-to-female and female-to-male transsexual patients both before and during cross-gender hormone treatment. This treatment involves administration of testosterone esters to women and of ethinyloestradiol and cyproterone acetate to men. RESULTS High dose sex steroid administration had marked effects on adrenal androgens levels, which decreased by 27-48% in males treated with ethinyloestradiol and increased by 23-70% in females treated with testosterone. CONCLUSION We conclude that administration of high doses of testosterone and oestradiol exert opposing effects on adrenal androgen production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 14:22:31