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Titolo:
MONOAMINE OXIDASES AND ALCOHOLISM .2. STUDIES IN ALCOHOLIC FAMILIES
Autore:
SUAREZ BK; HAMPE CL; PARSIAN A; CLONINGER CR;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
American journal of medical genetics
fascicolo: 5, volume: 60, anno: 1995,
pagine: 417 - 423
SICI:
0148-7299(1995)60:5<417:MOAA.S>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE SUSCEPTIBILITY GENES; PLATELET MAO ACTIVITY; BLOOD-PLATELETS; QUANTITATIVE TRAITS; COMPLEX SEGREGATION; ENZYME-ACTIVITY; X-CHROMOSOME; PLASMA; LINKAGE; LOCUS;
Keywords:
LINKAGE; AFFECTED SIB-PAIRS; GENDER DIFFERENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
B.K. Suarez et al., "MONOAMINE OXIDASES AND ALCOHOLISM .2. STUDIES IN ALCOHOLIC FAMILIES", American journal of medical genetics, 60(5), 1995, pp. 417-423

Abstract

Thirty-five alcoholic families have been studied to investigate the relationship between DNA markers at the monoamine oxidase (MAO) loci and 1) platelet activity levels and 2) alcoholism. A quantitative linkage analysis failed to reveal any evidence that the variation in activity levels cosegregates with the DNA markers. A sib-pair analysis did not reveal a significant excess of MAO haplotype sharing among alcoholicsibs, although the deviation from random sharing was in the directionconsistent with an X-linked component. A reanalysis of platelet MAO activity levels in a subset of these families revealed that the lower levels previously found in alcoholics is more likely due to the differences between males and females. Only among males and only when a ''broad'' definition of alcoholism is used (and MAO activity levels are transformed to normality) does it appear that alcoholics have depressed activities compared to nonalcoholics. Finally, when the confounding dueto gender difference is removed, no differences between type I and type II alcoholics are found in these families. (C) 1995 Wiley-Liss, Inc.

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Documento generato il 01/10/20 alle ore 04:10:31