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Titolo:
MONOAMINE OXIDASES AND ALCOHOLISM .1. STUDIES IN UNRELATED ALCOHOLICSAND NORMAL CONTROLS
Autore:
PARSIAN A; SUAREZ BK; TABAKOFF B; HOFFMAN P; OVCHINNIKOVA L; FISHER L;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 UNIV COLORADO,SCH MED,DEPT PHARMACOL DENVER CO 80262
Titolo Testata:
American journal of medical genetics
fascicolo: 5, volume: 60, anno: 1995,
pagine: 409 - 416
SICI:
0148-7299(1995)60:5<409:MOAA.S>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET MAO ACTIVITY; PSYCHIATRIC-DISORDERS; ENZYME-ACTIVITY; LOCUS; INHIBITOR; GENE; SCHIZOPHRENIA; HETEROGENEITY; ABSTINENCE; ETHANOL;
Keywords:
MAO ACTIVITY; DINUCLEOTIDE REPEATS; ALCOHOLISM; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
A. Parsian et al., "MONOAMINE OXIDASES AND ALCOHOLISM .1. STUDIES IN UNRELATED ALCOHOLICSAND NORMAL CONTROLS", American journal of medical genetics, 60(5), 1995, pp. 409-416

Abstract

Low platelet MAO activity has been associated with alcoholism, In order to evaluate the role of MAO genes in susceptibility to alcoholism, we have taken a biochemical and molecular genetic approach. The sampleconsisted of 133 alcoholic probands who were classified by subtypes of alcoholism and 92 normal controls, For those subjects typed for platelet MAO activity, alcoholics (N = 74) were found not to differ from the non-alcoholics controls (N = 34), Neither was there a significant difference between type I and type II alcoholics or between either subtype and normal controls. However, we do find significant differences between male and female alcoholics, but not between male and female controls, The allele frequency distribution for the MAO-A and MAO-B dinucleotide repeats is different between the alcoholic sample (N = 133) and the normal control sample (N = 92), In a two-way analysis of variance of MAO-B activity as a function of the allelic variation of each marker locus and diagnosis, there is no evidence for mean differences in activity levels for the different alleles, Our findings do not rule out a role for the MAO-B gene in controlling the enzyme activity becausethe dinucleotide repeats are located in introns. (C) 1995 Wiley-Liss,Inc.

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Documento generato il 28/09/20 alle ore 15:18:56