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Titolo:
CHROMOSOME MAPPING OF RMP-4, A GONAD-DEPENDENT GENE ENCODING HOST-RESISTANCE TO MOUSEPOX
Autore:
BROWNSTEIN DG; GRAS L;
Indirizzi:
YALE UNIV,SCH MED,COMPARAT MED SECT,333 CEDAR ST NEW HAVEN CT 06510
Titolo Testata:
Journal of virology
fascicolo: 11, volume: 69, anno: 1995,
pagine: 6958 - 6964
SICI:
0022-538X(1995)69:11<6958:CMORAG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE INNATELY RESISTANT; VIRUS-INDUCED MORTALITY; NATURAL-KILLER-CELLS; VACCINIA VIRUS; ECTROMELIA VIRUS; LETHAL INFECTION; INBRED MICE; MOSCOW-STRAIN; T-CELLS; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Brownstein e L. Gras, "CHROMOSOME MAPPING OF RMP-4, A GONAD-DEPENDENT GENE ENCODING HOST-RESISTANCE TO MOUSEPOX", Journal of virology, 69(11), 1995, pp. 6958-6964

Abstract

DBA/2 (D2) mice are susceptible and C57BL/6 (B6) mice are resistant to lethal mousepox, A congenic resistant strain, D2,B6-Rmp-4' (D2,R4), was developed by serially backcrossing male mice that survived ectromelia virus infection with D2 mice, beginning with (B6 x D2)F-1 mice, Male D2,R4 mice were at least 300-fold more resistant to lethal mousepoxthan male D2 mice. Female D2.R4 mice were 100-fold more resistant than male D2,R4 mice and 500-fold more resistant than female D2 mice. Neonatal gonadectomy prevented development of resistance in D2.R4 mice ofboth sexes, Differences in resistance between strains and between sexes correlated with restriction of virus replication in spleen and liver, but gender differences were less evident in liver than in spleen, High-resolution interval mapping of the 19 autosomes of D2,R4 mice using dispersed informative microsatellites as marker loci revealed a segment of distal chromosome I to be of B6 origin. Haplotypes for a markerlocus, D1Mit57, from the differential segment were determined in (D2,R4 x D2)F-1 x D2 backcross mice, which were then infected with ectromelia virus, Significantly more heterozygotes than homozygotes survived ectromelia virus infection in both sexes, Whereas nearly all survivingmales were heterozygotes, 44% of surviving females were homozygotes, These results indicate that resistance in D2.R4 mice is determined by a gonad-dependent gene on distal chromosome 1, provisionally named Rmp-4, and by an ovary-dependent factor that is not genetically linked toRmp-4.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:37:40