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Titolo:
EOSINOPHIL CATIONIC PROTEIN IN SERUM AND NASAL WASHES FROM WHEEZING INFANTS AND CHILDREN
Autore:
INGRAM JM; RAKES GP; HOOVER GE; PLATTSMILLS TAE; HEYMANN PW;
Indirizzi:
UNIV VIRGINIA,HLTH SCI CTR,DEPT PEDIAT,BLDG MR-4,ROOM 5061 CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,HLTH SCI CTR,DEPT PEDIAT CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,HLTH SCI CTR,DEPT INTERNAL MED CHARLOTTESVILLE VA 22908
Titolo Testata:
The Journal of pediatrics
fascicolo: 4, volume: 127, anno: 1995,
pagine: 558 - 564
SICI:
0022-3476(1995)127:4<558:ECPISA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY RESPONSIVENESS; INHALANT ALLERGENS; RESPIRATORY-TRACT; ANTIGEN CHALLENGE; IGE ANTIBODIES; LUNG-FUNCTION; ASTHMA; BLOOD; INFECTION; CHILDHOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Ingram et al., "EOSINOPHIL CATIONIC PROTEIN IN SERUM AND NASAL WASHES FROM WHEEZING INFANTS AND CHILDREN", The Journal of pediatrics, 127(4), 1995, pp. 558-564

Abstract

Objective: To compare eosinophil counts and concentrations of eosinophil cationic protein (ECP) in serum and nasal wash fluid from wheezinginfants and children with those from age-matched children without respiratory tract symptoms, Design: A case-control study of 71 children treated for wheezing and 59 control subjects in the University of Virginia Pediatric Emergency Department, The patients ranged from 2 months to 16 years of age. Eosinophil numbers and ECP concentrations were assessed in serum and nasal washes, Total serum IgE was measured and the radioallergosorbent test was used to measure IgE antibody to common inhalant allergens, Results: Among children less than the age of 2 years, markedly elevated levels of ECP (> 200 ng/ml) were measured in nasalwashes from 9 (41%) of 22 wheezing patients and 1 (6%) of 17 control subjects (p < 0.03), None of these children had a positive radioallergosorbent test result for IgE antibody to common aeroallergens or a nasal smear containing 10% eosinophils, Few of the wheezing children under 2 years of age had either increased concentrations of total IgE or ECP in their serum or an elevated total blood eosinophil count, After the age of 2 years, the percentage of patients with nasal ECP levels greater than 200 ng/ml was also significantly higher in wheezing children than in control subjects (p < 0.001), and a positive correlation wasobserved between ECP concentrations in their nasal washes and other eosinophil responses (total blood eosinophil counts, serum ECP levels, and nasal eosinophil counts), Conclusion: Increased concentrations of ECP were detected in nasal washes from wheezing infants and children, indicating that eosinophils may contribute to the pathogenesis of airway inflammation in some children who wheeze early in life.

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Documento generato il 31/05/20 alle ore 13:43:31