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Titolo:
PLASMA TESTOSTERONE SURGE AND LUTEINIZING-HORMONE-BETA (LH-BETA) FOLLOWING PARTURITION - LACK OF ASSOCIATION IN THE MALE-RAT
Autore:
MCGIVERN RF; HERMANS RHM; HANDA RJ; LONGO LD;
Indirizzi:
6363 ALVARADO CT,SUITE 200H SAN DIEGO CA 92120 SAN DIEGO STATE UNIV,DEPT PSYCHOL SAN DIEGO CA 92182 SCH MED LOMA LINDA,DEPT PHYSIOL,DIV PERINATAL BIOL LOMA LINDA CA 00000 SCH MED LOMA LINDA,DEPT OBSTET & GYNECOL LOMA LINDA CA 00000 LOYOLA UNIV,STRITCH SCH MED,DEPT CELL BIOL MAYWOOD IL 60153 LOYOLA UNIV,STRITCH SCH MED,DEPT ANAT & NEUROBIOL MAYWOOD IL 60153
Titolo Testata:
European journal of endocrinology
fascicolo: 3, volume: 133, anno: 1995,
pagine: 366 - 374
SICI:
0804-4643(1995)133:3<366:PTSAL(>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING HORMONE; HUMAN CHORIONIC-GONADOTROPIN; TESTICULAR STEROIDOGENESIS; SEX-DIFFERENCES; FETAL RATS; NEONATAL RATS; LEYDIG-CELLS; FEMALE RATS; SERUM; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.F. Mcgivern et al., "PLASMA TESTOSTERONE SURGE AND LUTEINIZING-HORMONE-BETA (LH-BETA) FOLLOWING PARTURITION - LACK OF ASSOCIATION IN THE MALE-RAT", European journal of endocrinology, 133(3), 1995, pp. 366-374

Abstract

Studies examining the role of luteinizing hormone (LII) in the initiation of the postnatal surge of testosterone in the male rat have produced ambiguous results. We examined the pattern of postnatal LH secretion in the newborn male rat, coincident with plasma testosterone levels, using a specific monoclonal antibody for LH-beta. In some males, we attempted to block LII secretion and the postnatal testosterone surge by injecting males with a gonadotropin-releasing hormone (GnRH) antagonist, an LH antibody or progesterone immediately after delivery by cesarean section on day 22, Following injection, animals were immediatelysacrificed (time 0) or housed in a humidified incubator maintained at30 degrees C until sacrifice at 60, 120, 240, 360 or 480 min after delivery, Plasma from individual animals was measured subsequently for LH-beta and testosterone by radioimmunoassay. Results revealed a postnatal surge of testosterone which peaked at 2.h after delivery in males from all treatment groups. This testosterone surge was not accompaniedby a postnatal rise in plasma LH-beta in any group, Administration ofthe GnRH antagonist or the ethanol vehicle produced a transient drop of approximately 25% in LH-beta levels at 60 min but did not decrease the postnatal testosterone surge in the same animals. Additional studies in untreated males and females born by cesarean section or natural birth also failed to reveal a postnatal rise in plasma LH-beta during the first 3 h after birth. Plasma levels in both sexes were significantly lower in animals delivered by cesarean section compared to naturalbirth. Overall, these results indicate that the postnatal surge of testosterone occurs without a corresponding surge of detectable LH-beta in the male rat.

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Documento generato il 25/11/20 alle ore 10:03:39