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Titolo:
PSYCHOLEINE, A NATURAL ALKALOID EXTRACTED FROM PSYCHOTRIA OLEOIDES, ACTS AS A WEAK ANTAGONIST OF SOMATOSTATIN
Autore:
RASOLONJANAHARY R; SEVENET T; VOEGELEIN FG; KORDON C;
Indirizzi:
UNIV AIX MARSEILLE 2,FAC MED,SECTEUR NORD,CNRS,UMR 9941,BD PIERRE DRAMARD F-13916 MARSEILLE 20 FRANCE INSERM,U159 F-75014 PARIS FRANCE CNRS,ICSN F-91190 GIF SUR YVETTE FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 285, anno: 1995,
pagine: 19 - 23
SICI:
0014-2999(1995)285:1<19:PANAEF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ANTERIOR-PITUITARY; ADENYLATE-CYCLASE; HORMONE;
Keywords:
PSYCHOLEINE; QUADRIGEMINE C; SOMATOSTATIN; GROWTH HORMONE; ADENYLATE CYCLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
R. Rasolonjanahary et al., "PSYCHOLEINE, A NATURAL ALKALOID EXTRACTED FROM PSYCHOTRIA OLEOIDES, ACTS AS A WEAK ANTAGONIST OF SOMATOSTATIN", European journal of pharmacology, 285(1), 1995, pp. 19-23

Abstract

The effects of psycholeine, a plant alkaloid, were investigated on binding of radiolabelled somatostatin ([I-125]N-Tyr-SRIF) and on somatostatin (SRIF)-induced inhibition of adenylate cyclase activity and growth hormone (GH) secretion by rat anterior pituitary cells. Psycholeinewas shown to displace specific binding of [I-125]N-Tyr-SRIF to pituitary membrane preparations, with an IC50 of 10(-5) M. At this concentration, psycholeine was also effective in significantly reducing the SRIF-induced inhibition of adenylate cyclase activity previously stimulated by growth hormone releasing factor (GRF). In parallel, it reduced the SRIF-induced inhibition of GH release stimulated by GRF in primary pituitary cell cultures in a dose-dependent manner. At a moderate concentration, the alkaloid affected neither adenylate cyclase activity nor GH release when applied in the absence of SRIF. These data suggest that psycholeine has antagonistic properties at the SRIF receptor. Quadrigemine C, a precursor of psycholeine, has a similar action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:18:28