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Titolo:
ABNORMAL BRAIN GLUCOSE-METABOLISM IN THE DELUSIONAL MISIDENTIFICATIONSYNDROMES - A POSITRON EMISSION TOMOGRAPHY STUDY IN ALZHEIMER-DISEASE
Autore:
MENTIS MJ; WEINSTEIN EA; HORWITZ B; MCINTOSH AR; PIETRINI P; ALEXANDER GE; FUREY M; MURPHY DGM;
Indirizzi:
NIA,NEUROSCI LAB,BLDG 10,RM 6C414 BETHESDA MD 20892
Titolo Testata:
Biological psychiatry
fascicolo: 7, volume: 38, anno: 1995,
pagine: 438 -
SICI:
0006-3223(1995)38:7<438:ABGITD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPGRAS SYNDROME; REDUPLICATIVE PARAMNESIA; HEMORRHAGE; DISORDERS; PATIENT; MEMORY; PET;
Keywords:
GLUCOSE BRAIN METABOLISM; DELUSION; DEMENTIA; FRONTAL LOBE; PARALIMBIC SYSTEM; LIMBIC SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Mentis et al., "ABNORMAL BRAIN GLUCOSE-METABOLISM IN THE DELUSIONAL MISIDENTIFICATIONSYNDROMES - A POSITRON EMISSION TOMOGRAPHY STUDY IN ALZHEIMER-DISEASE", Biological psychiatry, 38(7), 1995, pp. 438

Abstract

Brain lesions have been reported with increasing frequency in the delusional misidentification syndromes (DMS). This is the first controlled study to describe DMS regional cerebral metabolic rates of glucose (rCMRglc). We compared rCMPglc (using positron emission tomography) andneuropsychological data in 9 patients with DMS and Alzheimer dementia(AD), 15AD patients without DMS, and 17 healthy controls. The DMS group differed from the AD group without DMS in having significant hypometabolism in paralimbic (orbitofrontal and cingulate areas bilaterally)and left medial temporal areas, and significant bilateral normalized hypermetabolism in sensory association cortices (superior temporal andinferior parietal) without right left asymmetry. Compared to healthy controls, both AD groups had significant dorsolateral frontal hypometabolism bilaterally. No specific DMS neuropsychological profile was identified. Dysfunctional connections among multimodal association areas,paralimbic structures, and dorsolateral frontal cortex are proposed as the predisposing neural deficit underlying DMS, causing cognitive-perceptual-affective dissonance, which under specific conditions result in ''positive'' delusion formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:47:24