Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DELINEATION OF PRODUCING ABILITY OF IGG AND IGA SUBCLASSES BY NAIVE B-CELLS IN NEWBORN-INFANTS AND ADULT INDIVIDUALS
Autore:
YACHIE A; KONNO A; OHTA K; WADA T; SEKI H; TANIGUCHI N; MIYAWAKI T;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT PAEDIAT,13-1 TAKARAMACHI KANAZAWA ISHIKAWA920 JAPAN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 1, volume: 102, anno: 1995,
pagine: 204 - 209
SICI:
0009-9104(1995)102:1<204:DOPAOI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED IMMUNOGLOBULIN PRODUCTION; HUMAN CORD BLOOD; DIFFERENTIATION ABILITY; NEONATAL LYMPHOCYTES; REGULATORY FUNCTION; T-CELLS; MEMORY; SUBPOPULATIONS; PROLIFERATION; MATURATION;
Keywords:
NAIVE B CELLS; IGG SUBCLASS; IGA SUBCLASS; L-SELECTIN; MEMORY T CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A. Yachie et al., "DELINEATION OF PRODUCING ABILITY OF IGG AND IGA SUBCLASSES BY NAIVE B-CELLS IN NEWBORN-INFANTS AND ADULT INDIVIDUALS", Clinical and experimental immunology, 102(1), 1995, pp. 204-209

Abstract

Neonatal B cells with the naive (sIgD(+)) phenotype are able to generate IgG- and IgA-producing cells as well as IgM production in the presence of memory CD4(+) T cells expressing L-selectin (CD62L) in pokeweed mitogen-stimulated cultures. We used this system to examine comparatively the ability of naive B cells to produce IgG and IgA subclasses in newborn infants and adult individuals. Naive B cells were enriched from both donors on the basis of sIgD positivity, and memory (CD35RO(+)) CD4(+) T cells with CD62L expression were isolated from adults. We here demonstrate some differences in profiles of IgG and IgA subclass production between neonatal and adult naive B cells. In neonatal B cells, IgG1 and IgG3 were predominantly produced, but IgG2 and IgG4 production was virtually absent. Similar to neonatal B cells, adult naive B cells produced mainly IgG1 and IgG3, although memory (sIgD(-)) B cellsfrom adults secreted all of the IgG subclasses. It should be noted that low but detectable levels of IgG2 and IgG4 were found in adults' naive B cell cultures. Although IgA produced by neonatal B cells was exclusively IgA1, IgA2-secreting cells were identifiable in adult naive Bcells. The results suggest that further class switch of naive B cellsto IgG2, IgG4 and IgA2 in addition to IgG1 and IgG3 may be controlledby their own age-dependent maturation process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:28:01