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Titolo:
IS THE COURSE OF NEUROCYSTICERCOSIS MODIFIED BY TREATMENT WITH ANTIHELMINTHIC AGENTS
Autore:
CARPIO A; SANTILLAN F; LEON P; FLORES C; HAUSER WA;
Indirizzi:
COLUMBIA UNIV,GERTRUDE H SERGIEVSKY CTR,630 W 168TH ST,BOX 16 NEW YORK NY 10032 COLUMBIA UNIV,GERTRUDE H SERGIEVSKY CTR NEW YORK NY 10032 UNIV CUENCA,SCH MED CUENCA ECUADOR UNIV CUENCA,HLTH SCI RES INST CUENCA ECUADOR VICENTE CORRAL M HOSP,DEPT RADIOL CUENCA ECUADOR
Titolo Testata:
Archives of internal medicine
fascicolo: 18, volume: 155, anno: 1995,
pagine: 1982 - 1988
SICI:
0003-9926(1995)155:18<1982:ITCONM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL CYSTICERCOSIS; ALBENDAZOLE THERAPY; PRAZIQUANTEL; SEIZURES; ASSAY; CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Carpio et al., "IS THE COURSE OF NEUROCYSTICERCOSIS MODIFIED BY TREATMENT WITH ANTIHELMINTHIC AGENTS", Archives of internal medicine, 155(18), 1995, pp. 1982-1988

Abstract

Background: Neurocysticercosis, occasionally associated with long-term neurologic sequelae such as epilepsy or hydrocephalus, is more oftena condition characterized by a benign course and spontaneous remission without permanent neurologic symptoms. This variability in outcome has led to difficulties in the interpretation of studies of the effectiveness of drugs used to treat this condition. Objective: To evaluate the relative efficacy of two antihelminthic agents against each other and against symptomatic treatment alone. Methods: Randomized clinical trial of treatment of patients with newly identified active neurocysticercosis with oral prednisolone alone (27 patients), praziquantel with prednisolone (54 patients), or albendazole with prednisolone (57 patients). Results: At 6 months and at 1 year after treatment, there were no differences in the three treatment groups in terms of the proportionof patients who were free of cysts or the relative reduction of number of cysts. At 2 years, there was no difference in the proportion of patients free of seizures during the entire follow-up period. Early andlate sequelae occurred in a higher proportion of patients treated with praziquantel and albendazole, compared with those receiving only prednisolone. Conclusions: Previous reports of favorable response to treatment of neurocysticercosis with either praziquantel or albendazole are by no means definitive and may be a reflection of the natural history of the condition. The present study, with randomized treatment assignment and including a control group, raises questions as to what extent and in whom treatment with these drugs is effective, and suggests that treatment with antihelminthic agents maybe associated with an increased frequency of long-term sequelae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:37:11