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Titolo:
INTERLEUKIN-6 CAUSES HYPOCHOLESTEROLEMIA IN MIDDLE-AGED AND OLD RHESUS-MONKEYS
Autore:
ETTINGER WH; SUN WH; BINKLEY N; KOUBA E; ERSHLER W;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED,GEN INTERNAL MED & GERONTOL SECT WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27157 UNIV WISCONSIN,WISCONSIN REG PRIMATE RES CTR MADISON WI 00000 MADISON VA GRECC,INST AGING MADISON WI 00000
Titolo Testata:
The journals of gerontology. Series A, Biological sciences and medical sciences
fascicolo: 3, volume: 50, anno: 1995,
pagine: 137 - 140
SICI:
1079-5006(1995)50:3<137:ICHIMA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL CANCER CACHEXIA; CHOLESTEROL ACYLTRANSFERASE; RHEUMATOID-ARTHRITIS; SERUM-CHOLESTEROL; MORTALITY; LIPOPOLYSACCHARIDE; LECITHIN; PROTEIN; FALL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
W.H. Ettinger et al., "INTERLEUKIN-6 CAUSES HYPOCHOLESTEROLEMIA IN MIDDLE-AGED AND OLD RHESUS-MONKEYS", The journals of gerontology. Series A, Biological sciences and medical sciences, 50(3), 1995, pp. 137-140

Abstract

Background. Hypocholesterolemia is a risk factor for morbidity and mortality in older people. We have hypothesized that hypocholesterolemiain older people is due to the chronic effect of proinflammatory cytokines on lipoprotein metabolism. Methods. To test tile effects of the chronic administration of interleukin-6 (IL-6) on lipoprotein levels inmiddle-aged and old rhesus monkeys, five middle-aged and five old rhesus monkeys received a subcutaneous injection of recombinant human IL-6 (15 mu g/kg) for 28 days. Lipid, apolipoprotein, and albumin levels were measured at 0, 28, and 42 days after injection. Results. Total and HDL cholesterol levels fell by 16 and 23%, respectively, after IL-6 injections.;The concentrations of apolipoproteins Al and B also decreased. The changes in lipoprotein levels were accompanied by a decrease in albumin levels and body weight. Levels of lipids and plasma proteins returned toward normal 2 weeks after injections were stopped. There was no difference in response between middle-aged and older animals. Conclusions. Chronic IL-6 injections cause acquired hypocholesterolemia, hypoalbuminemia, and weight loss in nonhuman primates. These changesare similar to those seen in older persons with acquired hypocholesterolemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 06:31:27