Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ROLE OF TYROSINE KINASES IN LYMPHOCYTE-ACTIVATION - TARGETS FOR DRUG INTERVENTION
Autore:
HANKE JH; POLLOK BA; CHANGELIAN PS;
Indirizzi:
PFIZER INC,CENT RES,EASTERN POINT RD GROTON CT 06340
Titolo Testata:
Inflammation research
fascicolo: 9, volume: 44, anno: 1995,
pagine: 357 - 371
SICI:
1023-3830(1995)44:9<357:ROTKIL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; AMINO-TERMINAL DOMAIN; MICE LACKING P56(LCK); PERIPHERAL T-CELLS; SRC FAMILY KINASES; SIGNAL-TRANSDUCTION; PROTEIN-KINASE; ZETA-CHAIN; SH3 DOMAINS; PHOSPHATIDYLINOSITOL 3-KINASE;
Keywords:
TYROSINE KINASES; LYMPHOCYTES; DRUG TARGETS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
190
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Hanke et al., "ROLE OF TYROSINE KINASES IN LYMPHOCYTE-ACTIVATION - TARGETS FOR DRUG INTERVENTION", Inflammation research, 44(9), 1995, pp. 357-371

Abstract

Recent developments in our understanding of lymphocyte receptor-associated signalling events have offered many new potential targets for modifying antigen and cytokine receptor signalling events in immune-related diseases such as allergy, autoimmunity and transplant rejection. As discussed below, these targets are largely tissue-restricted and arefunctionally confined to a limited set of receptors. Therefore, it isanticipated that selective inhibitors of these signalling events would offer safe and effective therapies for immunologically-based diseases. First, we review T and B cell antigen receptor signalling as targets for inhibiting lymphocyte responses. Second, targets in lymphocyte cytokine receptor signalling pathways are discussed. Finally, we reviewstrategies for inhibition of receptor signalling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 08:26:43