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Titolo:
A ZFY-LIKE SEQUENCE IN FISH, WITH COMMENTS ON THE EVOLUTION OF THE ZFY FAMILY OF GENES IN VERTEBRATES
Autore:
ZIMMERER EJ; THRELKELD L;
Indirizzi:
MURRAY STATE UNIV,DEPT BIOL SCI MURRAY KY 42071
Titolo Testata:
Biochemical genetics
fascicolo: 7-8, volume: 33, anno: 1995,
pagine: 227 - 235
SICI:
0006-2928(1995)33:7-8<227:AZSIFW>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR-IIIA; SEX-DETERMINING REGION; ZINC-BINDING DOMAINS; Y-CHROMOSOME ENCODES; PROTEIN; MOUSE; EXPRESSION; FINGERS;
Keywords:
ZINC FINGER PROTEIN; ZFY GENES; EVOLUTION OF GENE FAMILIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Zimmerer e L. Threlkeld, "A ZFY-LIKE SEQUENCE IN FISH, WITH COMMENTS ON THE EVOLUTION OF THE ZFY FAMILY OF GENES IN VERTEBRATES", Biochemical genetics, 33(7-8), 1995, pp. 227-235

Abstract

ZFY-like genes have been observed in a variety of vertebrate species. Although originally implicated as the primary testis-determining genein humans and other placental mammals, more recent evidence indicatesa role(s) outside that of testis determination lit this study, DNA from five species of fish, Carasius auratus, Rivulus marmoratus, Xiphophorus maculatus, X. milleri, and X. nigrensis was subjected to Southernblot analysis using a PCR-amplified fragment of mouse ZFY-like sequence as a probe. Restriction fragment patterns were not polymorphic between sexes in any one species but showed a different pattern for each species. With one exception, Rivulus, a 3.1-kb band from the EcoRI digestion was common to all. Sequence and open reading frame analysis of this fragment showed a strong homology to other known vertebrate ZFY-like genes. Of particular interest in this gene is a novel third finger domain similar to one human and one alligator ZFY-like gene. Our studies and others provide evidence for a family of vertebrate ZFY genes, with those having this novel third finger being representative of the ancestral condition.

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Documento generato il 01/10/20 alle ore 00:29:16