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Titolo:
EPIDURAL DIAMORPHINE AND BUPIVACAINE STABILITY STUDY
Autore:
KREEGER L; COWIN P; NOBLEGRESTY J; NAYSMITH A;
Indirizzi:
ROYAL MARSDEN HOSP,FULHAM RD LONDON SW3 6JJ ENGLAND ST CHARLES HOSP LONDON ENGLAND CHARING CROSS HOSP,PEMBRIDGE PALLIAT CARE UNIT LONDON ENGLAND
Titolo Testata:
Palliative medicine
fascicolo: 4, volume: 9, anno: 1995,
pagine: 315 - 318
SICI:
0269-2163(1995)9:4<315:EDABSS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCAL-ANESTHETICS; ANALGESIA; INFUSION; MORPHINE; LABOR; PAIN;
Keywords:
ANALGESIA, EPIDURAL; BUPIVACAINE; DIACETYLMORPHINE; DRUG STABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
L. Kreeger et al., "EPIDURAL DIAMORPHINE AND BUPIVACAINE STABILITY STUDY", Palliative medicine, 9(4), 1995, pp. 315-318

Abstract

Diamorphine and bupivacaine are commonly used together for spinal analgesia, although stability data relating to the mixture of the two drugs have not actually been established. We therefore performed a stability study using high performance liquid chromatography for both drugs and the British Pharmacopoeia 2,6-dimethylaniline limit test for bupivacaine, over a period of eight days and at room temperature. Diamorphine and bupivacaine were combined in various concentrations in 100 ml bags for use with the Bard patient controlled analgesia pump. We found no significant change in concentration of either drug, and the 2,6-dimethylaniline limit test was well within set limits. We therefore conclude that it is safe to combine these two drugs in this way.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:42:21