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Titolo:
CAPTOPRIL DOES NOT AFFECT PLASMA ENDOTHELIN-1 DURING THROMBOLYSIS ANDREPERFUSION
Autore:
DIPASQUALE P; PATERNA S; PARRINELLO G; BUCCA V; CANNIZZARO S; PIPITONE F; MARINGHINI G; SCALZO S; LICATA G;
Indirizzi:
GF INGRASSIA HOSP,DIV CARDIOL,VAI VAL PLATANI 3 I-90144 PALERMO ITALY UNIV PALERMO,DEPT INTERNAL MED PALERMO ITALY
Titolo Testata:
International journal of cardiology
fascicolo: 2, volume: 51, anno: 1995,
pagine: 131 - 135
SICI:
0167-5273(1995)51:2<131:CDNAPE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA; CELLS;
Keywords:
ENDOTHELIN-1; ACUTE MYOCARDIAL INFARCTION (AMI); CAPTOPRIL; THROMBOLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
P. Dipasquale et al., "CAPTOPRIL DOES NOT AFFECT PLASMA ENDOTHELIN-1 DURING THROMBOLYSIS ANDREPERFUSION", International journal of cardiology, 51(2), 1995, pp. 131-135

Abstract

Studies showed that endothelin-1 (ET-1) was increased in the acute myocardial infarction (AMI). Experimental studies reported that captopril was able to reduce ET-1 secretion, and that ET-1 was increased during reperfusion. This study was aimed to verify if captopril was able toreduce plasma ET-1 during thrombolysis in AMI. Seventy-three patients, hospitalized for suspected AMI within 4 h from the onset of symptomssuitable for thrombolysis (Ist episode), Killip class 1-2, were randomized (double blind) into two groups: group 1 (37 pts), 8 F/29 M, received captopril, 6.25 mg, orally 15 min before thrombolysis. Group 2: (36 pts) 8 F/28 M, received placebo before thrombolysis. All patients met the reperfusion criteria. Plasma ET-1 were checked on admission, at1 h and at 2 h, after starting thrombolysis. Group 1 contained ten unstable angina, 17 anterior and ten inferior AMIs. Group 2 contained ten unstable angina, 16 anterior and ten inferior AMIs. Mean concentrations of ET-1: Unstable angina: group 1, basal - 4.56, at 1 h - 4.47, 2 h - 5.89 pg/ml; group 2: basal - 4.17, at 1 h - 4.59, 2 h - 5.24 pg/ml. Inferior AMI. group 1: basal - 6.87, 1 h - 7.75, 2 h - 8.47; group 2: basal - 6.34, 1 h - 6.68, 2 h - 7.98 pg/ml. Anterior AMI: group 1: basal - 7.17, 1 h - 7.93, 2 h - 10.76 pg/ml (between basal and 2-h samples P < 0.05); group 2: basal - 7.46, 1 h - 7.51, 2 h - 10.74 pg/ml. Differences between the two groups were not significant. Our data suggest that captopril does not affect plasma ET-1 during thrombolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:41:01