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Titolo:
BIOCHEMICAL-ANALYSIS OF MURINE WNT PROTEINS REVEALS BOTH SHARED AND DISTINCT PROPERTIES
Autore:
BURRUS LW; MCMAHON AP;
Indirizzi:
HARVARD UNIV,DEPT MOLEC & CELLULAR BIOL,BIOL LABS,16 DIVIN AVE CAMBRIDGE MA 02138 HARVARD UNIV,DEPT MOLEC & CELLULAR BIOL,BIOL LABS CAMBRIDGE MA 02138
Titolo Testata:
Experimental cell research
fascicolo: 2, volume: 220, anno: 1995,
pagine: 363 - 373
SICI:
0014-4827(1995)220:2<363:BOMWPR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTO-ONCOGENE INT-1; FIBROBLAST GROWTH-FACTOR; MOUSE DEVELOPMENT; XENOPUS EMBRYOS; NEURAL-TUBE; WINGLESS PROTEIN; BINDING-PROTEIN; EXPRESSION; CELLS; PROTOONCOGENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
L.W. Burrus e A.P. Mcmahon, "BIOCHEMICAL-ANALYSIS OF MURINE WNT PROTEINS REVEALS BOTH SHARED AND DISTINCT PROPERTIES", Experimental cell research, 220(2), 1995, pp. 363-373

Abstract

The murine Wnt family of proteins consists of at least 12 members that possess significant amino acid homology. Current evidence suggests that these proteins are secreted cell-signaling molecules which are likely to have multiple roles during both embryonic development and oncogenesis, Although the biochemical properties of Wnt-1 have been thoroughly examined, less is known about the characteristics of other Wnt family members. We have compared the properties of six murine Wnt proteins (Wnt-1, Wnt-3a, Wnt-5a, Wnt-5b, Wnt-6, and Wnt-7b) transiently expressed in COS cells. All members enter the endoplasmic reticulum (ER) and are glycosylated. However, all six Wnt proteins are primarily retained in the ER in association with BiP, a resident ER protein that bindsto improperly folded proteins and prevents their secretion and/or promotes proper folding. Although all Wnt family members examined are similarly processed, one notable difference was identified. Whereas addition of suramin to COS cell cultures significantly increases the levelsof all six Wnts in the medium, the addition of heparin only influences the levels of Wnt-1, Wnt-6, and Wnt-7b. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:30:59