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Titolo:
D1 D2 ACTIONS OF DOPAMINERGIC DRUGS STUDIED WITH [C-14] 2-DEOXYGLUCOSE AUTORADIOGRAPHY/
Autore:
TRUGMAN JM;
Indirizzi:
UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROL,BOX 394 CHARLOTTESVILLE VA 22908
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 5, volume: 19, anno: 1995,
pagine: 795 - 810
SICI:
0278-5846(1995)19:5<795:DDAODD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-14 2-DEOXYGLUCOSE AUTORADIOGRAPHY; 6-HYDROXYDOPAMINE LESIONED RATS; CEREBRAL GLUCOSE-UTILIZATION; SUBSTANTIA NIGRA LESIONS; GAMMA-AMINOBUTYRIC-ACID; PARS RETICULATA NEURONS; L-DOPA; RECEPTOR STIMULATION; D1-DOPAMINE AGONIST; C-FOS;
Keywords:
BASAL GANGLIA; 2-DEOXYGLUCOSE AUTORADIOGRAPHY; D1 DOPAMINE RECEPTOR; D2 DOPAMINE RECEPTOR; PARKINSONS DISEASE; REGIONAL CEREBRAL GLUCOSE UTILIZATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Trugman, "D1 D2 ACTIONS OF DOPAMINERGIC DRUGS STUDIED WITH [C-14] 2-DEOXYGLUCOSE AUTORADIOGRAPHY/", Progress in neuro-psychopharmacology & biological psychiatry, 19(5), 1995, pp. 795-810

Abstract

1. To define the neural circuits activated by dopaminergic stimulation in rat models of parkinsonism, the author studied the effects of L-dopa and selective D1 and D2 agonists on RCGU in rats with unilateral 6-OHDA substantia nigra lesions. 2. Systemic administration of L-dopa markedly increased RCGU in the EP and SNr ipsilateral to the nigral lesion; it is suggested that this represents metabolic activity primarilyin axon terminals of GABAergic striatal projection neurons. These effects were reproduced by selective D1, but not D2, dopamine agonists, and were blocked completely by a D1 antagonist, indicating their critical dependence on D1 stimulation. L-dopa moderately increased RCGU in the STN; this effect was reproduced by D1 and D2 agonists and was blocked completely only by combined D1 and D2 antagonist pretreatment. 3. The RCGU data support a direct stimulatory action of dopamine, formed from L-dopa, on D1 receptor-bearing striatal GABAergic neurons projecting to the EP and SNr as well as a net stimulatory action on the GP output to the STN. 4. The marked DI-mediated RCGU increase in the SNr ipsilateral to the dopamine depletion contrasts with the modest increase seen on the contralateral side and in naive rats, suggesting that the enhanced RCGU response to D1 stimulation is an index of dopaminergic supersensitivity. The stimulatory effect of the DI agonist SKF 38393 onRCGU in the SNr is enhanced 6-12 hours after acute dopamine depletionwith reserpine/AMPT indicating that supersensitive responses develop within this rapid time frame. 5. The RCGU data indicate that D1 receptor stimulation contributes importantly, in an anatomically selective manner, to the effects of L-dopa on basal ganglia circuits and that theresponse to DI stimulation is rapidly modifiable by dopamine depletion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:30:51