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Titolo:
QUANTITATIVE DNA ANALYSIS OF AN INTRACEREBRALLY TRANSPLANTED BRAIN-TUMOR MODEL AFTER EXPERIMENTAL CHEMOTHERAPY WITH BCNU AND CCNU
Autore:
SCHLEGEL J; STUMM G; RUSCHOFF J; MENNEL HD;
Indirizzi:
UNIV MARBURG KLIN,NEUROPATHOL ABT D-35033 MARBURG GERMANY UNIV REGENSBURG,INST PATHOL W-8400 REGENSBURG GERMANY
Titolo Testata:
Experimental and toxicologic pathology
fascicolo: 4, volume: 47, anno: 1995,
pagine: 313 - 318
SICI:
0940-2993(1995)47:4<313:QDAOAI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GLIOMAS; LESIONS; RATS;
Keywords:
BRAIN TUMOR, TRANSPLANTED; TRANSPLANTED BRAIN TUMOR; DNA-CONTENT, BRAIN TUMOR; CHEMOTHERAPY, EXPERIMENTAL; NEUROONCOLOGY; NERVOUS SYSTEM, TUMORS; NITROSOUREA COMPOUNDS; GLIOMA, MALIGNANT, RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J. Schlegel et al., "QUANTITATIVE DNA ANALYSIS OF AN INTRACEREBRALLY TRANSPLANTED BRAIN-TUMOR MODEL AFTER EXPERIMENTAL CHEMOTHERAPY WITH BCNU AND CCNU", Experimental and toxicologic pathology, 47(4), 1995, pp. 313-318

Abstract

In the present study we investigated the susceptibility of high passages of the rat glial transplantation tumour G-XIII to chemotherapy using nitrosourea compounds. We observed a significant increase in lifespan (ILS) of animals treated with BCNU (37 %, p < 0.01) and CCNU (27 %,p < 0.01). There were no difference in the efficiency between these two substances. Using a semi-quantitative score system no histopathological changes were observed which were associated with the response to therapy. The only predicative parameter in the present study was the quantitative DNA distribution pattern. There was a close correlation between treatment and the occurrence of unimodal DNA distribution patterns indicating clonal regrowth of recurrent tumours. Moreover, we also observed a correlation of the DNA distribution pattern of recurrent tumours with the result of experimental chemotherapy. Survival times of animals suffering from tumours containing unimodal DNA histogram was significantly longer than survival times of rats with multimodal DNA distribution, i.e. bimodal or broad DNA histograms. A unimodal, near-diploid stem line was only present in treated animals suggesting that these clones are more resistant against therapy using nitrosourea compounds. Our data indicate DNA cytophotometry as comprehensive tool for themonitoring of therapy response and the design of experimental chemotherapy using rat glial tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:44:18