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Titolo:
HUMAN COLON PRODUCES FULLY PROCESSED GLUCAGON-LIKE PEPTIDE-1 (7-36)AMIDE
Autore:
DEACON CF; JOHNSEN AH; HOLST JJ;
Indirizzi:
UNIV COPENHAGEN,PANUM INST,DEPT MED PHYSIOL,BLEGDAMSVEJ 3 DK-2200 COPENHAGEN N DENMARK UNIV COPENHAGEN,RIGSHOSP,DEPT CLIN BIOCHEM COPENHAGEN DENMARK
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 372, anno: 1995,
pagine: 269 - 272
SICI:
0014-5793(1995)372:2-3<269:HCPFPG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG SMALL-INTESTINE; PANCREAS; PROGLUCAGON; IMMUNOREACTIVITY; ENTEROGLUCAGON; LOCALIZATION; GLICENTIN; GLUCOSE; PLASMA; GLP-1;
Keywords:
GLUCAGON-LIKE PEPTIDE-1; PROGLUCAGON PROCESSING; HUMAN COLON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Deacon et al., "HUMAN COLON PRODUCES FULLY PROCESSED GLUCAGON-LIKE PEPTIDE-1 (7-36)AMIDE", FEBS letters, 372(2-3), 1995, pp. 269-272

Abstract

The human colon contains many open-type endocrine cells which expressthe preproglucagon gene and possess glucagon-like peptide-1 (GLP-1) immunoreactivity, but the molecular form of the peptide is unknown. Acid ethanol extracts of human colon (n = 4) were subjected to gel filtration and successive purification by high-pressure liquid chromatography, monitored by specific RIAs. A single GLP-1-immunoreactive peak was isolated and identified as GLP-1 (7-36)amide by amino acid sequence analysis and mass spectrometry. We conclude that proglucagon is processed in the large intestine in the same manner as in the small intestine,and results in the formation of fully processed biologically active GLP-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:11:50