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Titolo:
MULTISUBUNIT RECEPTORS IN THE IMMUNE-SYSTEM AND THEIR ASSOCIATION WITH THE CYTOSKELTON - IN SEARCH OF FUNCTIONAL-SIGNIFICANCE
Autore:
CAPLAN S; BANIYASH M;
Indirizzi:
HEBREW UNIV JERUSALEM,HADASSAH MED SCH,LAUTENBERG CTR GEN & TUMOR IMMUNOL,POB 12272 IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Immunologic research
fascicolo: 2, volume: 14, anno: 1995,
pagine: 98 - 118
SICI:
0257-277X(1995)14:2<98:MRITIA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL ANTIGEN RECEPTOR; PROTEIN-TYROSINE KINASE; HIGH-AFFINITY RECEPTOR; ACTIN-BINDING PROTEIN; FC-EPSILON-RI; MEDIATED SIGNAL-TRANSDUCTION; LYMPHOCYTE MEMBRANE-PROTEINS; EPIDERMAL LANGERHANS CELLS; LIGAND-INDUCED ASSOCIATION; GTPASE-ACTIVATING PROTEIN;
Keywords:
T CELL ANTIGEN RECEPTOR; B CELL ANTIGEN RECEPTOR; FC-EPSILON RECEPTOR; CYTOSKELETON; SIGNAL TRANSDUCTION; T CELL ACTIVATION; EPIDERMAL GROWTH FACTOR RECEPTOR; INTEGRIN RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
150
Recensione:
Indirizzi per estratti:
Citazione:
S. Caplan e M. Baniyash, "MULTISUBUNIT RECEPTORS IN THE IMMUNE-SYSTEM AND THEIR ASSOCIATION WITH THE CYTOSKELTON - IN SEARCH OF FUNCTIONAL-SIGNIFICANCE", Immunologic research, 14(2), 1995, pp. 98-118

Abstract

Various multisubunit receptors of the immune system share similarities in structure and induce closely related signal transduction pathwaysupon ligand binding. Examples include the T cell antigen receptor (TCR), the B cell antigen receptor (BCR), and the high-affinity receptor for immunoglobulin E (Fc epsilon RI). Although these receptors are devoid of intrinsic kinase activity, they can associate with a similar array of intracellular kinases, phosphatases and other signaling molecules. Furthermore, these receptor complexes all form an association withthe cytoskeletal matrix. In this review, we compare the structural and functional characteristics of the TCR, BCR and Fc epsilon RI. We examine the role of the cytoskeleton in regulating receptor-mediated signal transduction, as analyzed in other well-characterized receptors, including the epidermal growth factor receptor and integrin receptors. On the basis of this evidence, we review the current data depicting a cytoskeletal association for multisubunit immune system receptors and explore the potential bearing of this interaction on signaling function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:23:59