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Titolo:
SELECTIVE MECHANISMS UTILIZED BY PERSISTENT AND ONCOGENIC VIRUSES TO INTERFERE WITH ANTIGEN-PROCESSING AND PRESENTATION
Autore:
EHRLICH RE; WISE GS;
Indirizzi:
TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT CELL RES & IMMUNOL IL-69978 RAMAT AVIV ISRAEL
Titolo Testata:
Immunologic research
fascicolo: 2, volume: 14, anno: 1995,
pagine: 77 - 97
SICI:
0257-277X(1995)14:2<77:SMUBPA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MHC CLASS-I; CYTOTOXIC LYMPHOCYTES-T; EPSTEIN-BARR-VIRUS; CYTO-TOXIC LYMPHOCYTES; CERVICAL INTRAEPITHELIAL NEOPLASIA; MARROW-TRANSPLANT RECIPIENTS; LIMITING DILUTION ANALYSIS; CELLULAR IMMUNE-RESPONSES; TRANSFORMED RAT-CELLS; NF-KAPPA-B;
Keywords:
CLASS I MHC; PERSISTENT VIRUSES; ONCOGENIC VIRUSES; ANTIGEN PROCESSING; ANTIGEN PRESENTATION; PEPTIDE TRANSPORTER; CHAPERONE; TRANSCRIPTIONAL REGULATION; ASSEMBLY AND TRANSPORT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
165
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Ehrlich e G.S. Wise, "SELECTIVE MECHANISMS UTILIZED BY PERSISTENT AND ONCOGENIC VIRUSES TO INTERFERE WITH ANTIGEN-PROCESSING AND PRESENTATION", Immunologic research, 14(2), 1995, pp. 77-97

Abstract

Cell-mediated immunity is effective against cells harboring active virus replication, and is critical for the elimination of ongoing infections, regression of virus-associated tumors, and reducing or preventing the reactivation of persistent viruses. The capacity of persistent and oncogenic viruses to maintain a long-term relationship with their host presupposes viral mechanisms for circumventing antiviral defenses. By suppressing the expression of molecules associated with antigen processing and presentation, viruses abrogate the major immune mechanismthat deals with the elimination of infected and tumor cells. This is accomplished either by transcriptional downregulation of genes encoding class I MHC antigens, peptide transporter molecules, and the proteasome-associated LMP subunits, or by interfering with transport of classI molecules to the cell surface. In some cases viruses shut off the expression of most viral proteins during latency or express mainly nonimmunogenic or antagonistic peptide epitopes. This review describes selective mechanisms utilized by viruses for interference with antigen processing and presentation, and addresses their significance for in vivo viral persistence and tumor progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 08:05:35