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Titolo:
CYTOPLASMIC MOTILITY REFLECTS PHAGOCYTIC-ACTIVITY IN ALVEOLAR MACROPHAGES FROM DOG LUNGS
Autore:
YAMAYA M; FUKUSHIMA T; SEKIZAWA K; OHRUI T; SASAKI H;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU,1-1 SEIRYO MACHI SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU SENDAI MIYAGI 980 JAPAN
Titolo Testata:
Respiration physiology
fascicolo: 2, volume: 101, anno: 1995,
pagine: 199 - 205
SICI:
0034-5687(1995)101:2<199:CMRPIA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHALASIN-B; PULMONARY MACROPHAGES; MECHANISMS; PARTICLES; DECREASE; BINDING; PROTEIN;
Keywords:
CYTOSKELETON; ALVEOLAR MACROPHAGES; MACROPHAGES (ALVEOLAR); CYTOPLASMIC MOTILITY; MAMMALS (DOG);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Yamaya et al., "CYTOPLASMIC MOTILITY REFLECTS PHAGOCYTIC-ACTIVITY IN ALVEOLAR MACROPHAGES FROM DOG LUNGS", Respiration physiology, 101(2), 1995, pp. 199-205

Abstract

To determine whether cytoplasmic motility relates to phagocytic activity of alveolar macrophages (AM), we measured the remanent field strength (RFS) from the AM containing Fe3O4 particles (5 X 10(6) cells) andthe number of phagocytized fluorescent latex spheres in the AM without having Fe3O4 particles (10(6) cells) harvested by broncho-alveolar lavage from dog lungs in vitro. Cytoplasmic motility was estimated fromthe relaxation rate (lambda(o); min(-1)) calculated from the decay curve of RFS and the number of phagocytized latex spheres was counted using fluorescent microscopy after the addition of latex spheres (5 X 10(7)). The tumor necrosis factor increased both lambda(o) and the number of phagocytized latex spheres, and cytochalasin D and colchicine decreased them in a concentration-dependent fashion. Increases and decreases in lambda(o) induced by drugs paralleled the number of phagocytized latex spheres. These results suggest that cytoplasmic motility reflects phagocytic activity of AM and both cytoplasmic movement and phagocytosis may be regulated by a similar mechanism in the cytoskeletal system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:06:07