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Titolo:
RECURRENT LARYNGEAL NERVE ACTIVATION BY ALPHA(2) ADRENERGIC AGONISTS IN GOATS
Autore:
HEDRICK MS; RYAN ML; BISGARD GE;
Indirizzi:
UNIV WISCONSIN,DEPT COMPARAT BIOSCI,2015 LINDEN DR W MADISON WI 53706 UNIV WISCONSIN,DEPT COMPARAT BIOSCI MADISON WI 53706 CALIF STATE UNIV HAYWARD,DEPT BIOL SCI HAYWARD CA 94542
Titolo Testata:
Respiration physiology
fascicolo: 2, volume: 101, anno: 1995,
pagine: 129 - 137
SICI:
0034-5687(1995)101:2<129:RLNABA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS; CLONIDINE; EXPIRATION; NUCLEUS; INVITRO; HUMANS; SLEEP; RAT;
Keywords:
APNEA, (CENTRAL); CONTROL OF BREATHING, (RESPIRATORY ARRHYTHMIA); MAMMALS, (GOAT); NERVES, (RECURRENT LARYNGEAL); PATTERN OF BREATHING; PHARMACOLOGICAL AGENTS, (ALPHA(2) AGONISTS, CLONIDINE, GUANABENZ);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Hedrick et al., "RECURRENT LARYNGEAL NERVE ACTIVATION BY ALPHA(2) ADRENERGIC AGONISTS IN GOATS", Respiration physiology, 101(2), 1995, pp. 129-137

Abstract

The purpose of this study was to test the hypothesis that respiratoryarrhythmias and apneas induced by alpha(2) agonists in anesthetized goats are associated with an increase of upper airway expiratory-related activity, rather than a general depression of breathing. Activities of phrenic (Phr) and recurrent laryngeal nerves (RLN) were recorded inresponse to the alpha(2) agonists clonidine (0.5-3.0 mu g . kg(-1) i.v.) or guanabenz (7.0-20.0 mu g kg(-1) i.v.) in ten chloralose-anesthetized goats. Injection of either alpha(2) agonist resulted in respiratory arrhythmias with a greater than seven-fold increase in TE and a 30% reduction in TL. During apneas RLN expiratory-related activity remained tonic until the next Phr burst, consistent with our hypothesis. Cessation of Phr activity during hypocapnia also resulted in a tonic increase of RLN expiratory activity; and injection of NaCN (50 mu g . kg(-1) i.v.) increased Phr and RLN inspiratory activities, while attenuating RLN expiratory-related activity, Inspiratory and expiratory-related activity of RLN motoneurons appear to be reciprocally modulated by alpha(2) agonists or changes in central or peripheral chemoreceptor drive. The results indicate that central apneas and respiratory arrhythmias may be associated with alpha(2)-adrenoceptor modulation of laryngeal expiratory-related activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:30:59