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Titolo:
URETERAL GROWTH IN A GOETTINGEN MINIPIG INDUCED BY EPIDERMAL GROWTH-FACTOR - A CASE-REPORT
Autore:
VINTERJENSEN L; JUHL CO; DJURHUUS JC; DAJANI EZ; TEGLBJAERG PS; UVELIUS B; NEXO E;
Indirizzi:
AARHUS UNIV HOSP,DEPT CLIN BIOCHEM,KH,NORREBROGADE 44 DK-8000 AARHUS C DENMARK AARHUS UNIV,INST EXPTL CLIN RES DK-8000 AARHUS DENMARK INT DRUG DEV CONSULTANTS LONG GROVE IL 00000 AALBORG HOSP,INST PATHOL AALBORG DENMARK UNIV LUND HOSP,DEPT UROL LUND SWEDEN
Titolo Testata:
Scandinavian journal of urology and nephrology
, , anno: 1995, supplemento:, 172
pagine: 109 - 115
SICI:
0036-5599(1995):<109:UGIAGM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRA-CYTOPLASMIC LUMINA; SMOOTH-MUSCLE CELLS; BLADDER; RAT; UROTHELIUM; SECRETION; RECEPTOR; MITOGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
L. Vinterjensen et al., "URETERAL GROWTH IN A GOETTINGEN MINIPIG INDUCED BY EPIDERMAL GROWTH-FACTOR - A CASE-REPORT", Scandinavian journal of urology and nephrology, 1995, pp. 109-115

Abstract

We have recently discovered that prolonged systemic administration ofepidermal growth factor (EGF) induces a remarkable growth of all walllayers of the urinary tract in minipigs. In the present paper, we report the most pronounced changes induced by 4 weeks of systemic EGF challenge in two pigs treated for four weeks with either solvent or EGF (30 mu g/kg/day), respectively. The EGF treated ureter was longer and thicker with an approximately four fold increase in diameter. All wall layers were enlarged. The urothelium was increased from 5 to 10 cellular rows with basal hyperplasia and an increased number of goblet cellsand cells with intracytoplasmic lumina in the luminal half. In the muscular coat, the bundles of hypertrophied cells and intervening connective tissue were enlarged. The present paper suggests a possible in vivo approach to increase the amount of tissue needed in reconstructive surgery of the urinary tract.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:58:25