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Titolo:
IN-VITRO ANTIBACTERIAL ACTIVITY AND BETA-LACTAMASE STABILITY OF A NEWCARBAPENEM, BO-2727
Autore:
INOUE K; HAMANA Y; MITSUHASHI S;
Indirizzi:
EPISOME INST FUJIMI GUNMA 37101 JAPAN
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 10, volume: 39, anno: 1995,
pagine: 2331 - 2336
SICI:
0066-4804(1995)39:10<2331:IAAABS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROPEPTIDASE-I; RENAL DIPEPTIDASE; INVITRO ACTIVITY; ANTIBIOTICS; THIENAMYCIN; IMIPENEM; LJC10,627;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
K. Inoue et al., "IN-VITRO ANTIBACTERIAL ACTIVITY AND BETA-LACTAMASE STABILITY OF A NEWCARBAPENEM, BO-2727", Antimicrobial agents and chemotherapy, 39(10), 1995, pp. 2331-2336

Abstract

The in vitro activity of BO-2727, a new carbapenem, was compared withthose of meropenem, biapenem, imipenem, and ceftazidime. BO-2727 was four- or eightfold more active than the other carbapenems against methicillin-resistant staphylococci and Pseudomonas aeruginosa strains, including imipenem- and ceftazidime-resistant bacteria. BO-2727 was quite stable to penicillinases, cephalosporinases, and oxyiminocephalosporinases, but not to metallo-beta-lactamase. Time-kill studies against Staphylococcus aureus Smith, Escherichia coli ML4707, and P. aeruginosaGN11189 showed that BO-2727 has potent bactericidal activity at concentrations greater than the MIC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 23:43:27