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Titolo:
STIMULATION OF TUMOR-GROWTH IN-VITRO AND IN-VIVO BY SURAMIN ON THE VX2 MODEL
Autore:
RAMIREZ LH; JULIERON M; BONNAY M; KOSCIELNY S; ZHAO ZX; GOUYETTE A; MUNCK JN;
Indirizzi:
INST GUSTAVE ROUSSY,DEPT MED,39 RUE CAMILLE DESMOULINS F-94800 VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT MED F-94800 VILLEJUIF FRANCE INST GUSTAVE ROUSSY,DEPT CHIRURG CERVICOFACIALE F-94800 VILLEJUIF FRANCE INST GUSTAVE ROUSSY,BIOL CLIN LAB F-94800 VILLEJUIF FRANCE INST GUSTAVE ROUSSY,PHARMACOL CLIN LAB,CNRS,URA 147 F-94800 VILLEJUIFFRANCE
Titolo Testata:
Investigational new drugs
fascicolo: 1, volume: 13, anno: 1995,
pagine: 51 - 53
SICI:
0167-6997(1995)13:1<51:SOTIAI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTATE-CANCER; CELLS;
Keywords:
SURAMIN; VX2 TUMOR; PHARMACOKINETICS; TUMOR PROMOTION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
L.H. Ramirez et al., "STIMULATION OF TUMOR-GROWTH IN-VITRO AND IN-VIVO BY SURAMIN ON THE VX2 MODEL", Investigational new drugs, 13(1), 1995, pp. 51-53

Abstract

Suramin is an antitrypanosomal compound with confirmed efficacy against several human malignancies. It is generally assumed that its mechanism of action includes the interaction with different growth factors, unlike most of the anticancer drugs. Its anticancer activity has not been tested in vivo against squamous cell carcinoma. The purpose of this study was to assess the efficacy and toxicity of suramin in vivo andin vitro on the VX2 tumor model at therapeutic monitored plasma concentrations. We determined the pharmacokinetics of suramin in rabbits, and modelized its administration in order to obtain plasma concentrations between 150 and 300 mu g/ml throughout the treatment course of 3 weeks. Under these conditions, antitumor effects of suramin were evaluated in vivo by comparing liver tumor involvement in suramin-treated andcontrol rabbits. Liver involvement was quantified by image analysis and in vitro effects were also determined at the same concentrations. In vivo, suramin promoted liver tumor growth significantly (p < 0.05), compared to untreated controls. In vitro, suramin significantly stimulated tumor cell growth at concentrations above 200 mu g/ml (p < 0.01). Suramin may have stimulatory effects on tumor growth in squamous cellcarcinoma at relevant plasma drug concentrations. Caution should be taken in further trials in patients with squamous cell carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:06:40