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Titolo:
T-LYMPHOCYTES FROM VOLUNTEERS IMMUNIZED WITH IRRADIATED PLASMODIUM-FALCIPARUM SPOROZOITES RECOGNIZE LIVER AND BLOOD-STAGE MALARIA ANTIGENS
Autore:
KRZYCH U; LYON JA; JAREED T; SCHNEIDER I; HOLLINGDALE MR; GORDON DM;
Indirizzi:
WALTER REED ARMY INST RES,DEPT IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOLWASHINGTON DC 20307 WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOLWASHINGTON DC 20307 US FDA,CTR BIOL EVALUAT & RES,DIV ALLERG PROD & PARASITOL BETHESDA MD20852
Titolo Testata:
The Journal of immunology
fascicolo: 8, volume: 155, anno: 1995,
pagine: 4072 - 4077
SICI:
0022-1767(1995)155:8<4072:TFVIWI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEROZOITE SURFACE-ANTIGEN; CIRCUMSPOROZOITE PROTEIN; INFECTED ERYTHROCYTES; PROTECTIVE IMMUNITY; CELL CLONES; CS PROTEIN; BERGHEI; EXPRESSION; EPITOPES; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
U. Krzych et al., "T-LYMPHOCYTES FROM VOLUNTEERS IMMUNIZED WITH IRRADIATED PLASMODIUM-FALCIPARUM SPOROZOITES RECOGNIZE LIVER AND BLOOD-STAGE MALARIA ANTIGENS", The Journal of immunology, 155(8), 1995, pp. 4072-4077

Abstract

The model of protective immunity induced by immunization with irradiated plasmodia sporozoites (SPZ) has become the prototype for a promising vaccine strategy based on Ab and CTL responses directed against pre-erythrocytic stage Ags, in particular the circumsporozoite protein (CSP) and sporozoite surface protein 2 (SSP2). However, results from recently conducted vaccine studies suggest that T cell responses directedagainst additional specificities might also be required for protection. We have tested this hypothesis by examining human T lymphocytes from irradiated Plasmodium falciparum SPZ-immune volunteers for proliferative reactivities to parasitized red blood cells (pRBC) and recombinant proteins and synthetic peptides representing certain liver and bloodstage Ags. In this work, we report that although SPZ-induced protective immunity is stage-specific, SPZ-immune lymphocytes recognized determinants associated with erythrocytic and liver stage parasites. Thus, protective immunity induced by irradiated SPZ may depend upon responses against pre-erythrocytic Ags in addition to CSP and SSP2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 00:32:26